Figure 1. Discovery Analysis of 2320 Individuals With Primary Open-Angle Glaucoma and 2121 Age-Matched Control Individuals.
Single-nucleotide polymorphisms (SNPs) were only considered if they were assessed across all 4 genome-wide association discovery study sites. A total of 6 734 161 SNPs are included in this figure. The blue horizontal line indicates a threshold for suggestive statistical significance commonly used in genome-wide association studies (P = 10−5) and the red horizontal line indicates the threshold for genome-wide significance (P = 5 × 10−8). Multiple SNPs at the gene encoding for amyloid-β A4 precursor protein-binding family B member 2 (APBB2) have a significant association with primary open-angle glaucoma disease risk.