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Inhibition of NLRP3 suppressed the downstream signaling of IL-1β and IL-18 activated by uric acid. In cells pretreated with uric acid (0, 6, 9, 12 mg/dl) for 24 h, with or without MCC950, the levels of IL-1β (A) and IL-18 (B) were detected by ELISA. Data are expressed as mean ±SD. * p<0.05, *** p<0.001 vs. cells treated with 0 mg/ml uric acid. # p<0.05 vs. cells only treated with uric acid.
