Table 1. Baseline Clinical Characteristics.
| Clinical Characteristic | No. (%)a |
|---|---|
| Demographics | |
| Sex | |
| Women | 26 (87) |
| Men | 4 (13) |
| Age at enrollment, median (IQR), y | 66 (54-72) |
| Race and ethnicity, No./No. (%) | |
| White | 21/28 (75) |
| Black/African American | 7/28 (25) |
| Hispanic | 4/25 (16) |
| Nonischemic cardiomyopathy, No./No. (%) | 29/29 (100) |
| QRS after consent, median (IQR), ms | 152 (142-160) |
| LBBB after consent | 30 (100) |
| Sinus rhythm after consent | 29 (97) |
| Comorbidities, Patient History | |
| Diabetes at baseline | 6 (20) |
| Hypertension at baseline | 17 (57) |
| History of ventricular arrhythmias | 3 (10) |
| History of atrial arrhythmias | 8 (27) |
| Anthracycline history, No./No. (%) | 24/29 (83) |
| Time since cancer diagnosis, median (IQR), y | 13.8 (12.7) |
| Age at cancer diagnosis, median (IQR), y | 52 (40-59) |
| History of breast cancer | 22 (73) |
| History of leukemia or lymphoma | 6 (20) |
| History of sarcomas | 2 (7) |
| Physiologic and Laboratory Parameters at Baseline | |
| Blood urea nitrogen, median (IQR) [No. of patients], mg/dL | 20 (15-27) [27] |
| Creatinine, median (IQR) [No. of patients], mg/dL | 0.95 (0.80-1.25) [28] |
| New York Heart Association classb | |
| II | 17 (57) |
| III | 13 (43) |
| Blood pressure, median (IQR), mm Hg | |
| Systolic | 121.5 (116-133) |
| Diastolic | 70.5 (60-77) |
| Medical Therapy Use at Baseline | |
| β-Blocker | 28 (93) |
| ACEI or ARB | 23 (77) |
| Loop diuretic | 28 (93) |
| Aldosterone antagonist | 15 (50) |
Abbreviations: ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; IQR, interquartile range; LBBB, left bundle-branch block.
SI conversion factors: To convert creatinine to μmol/L, multiply by 88.4; urea nitrogen to mmol/L, multiply by 0.357.
a
Unless otherwise stated.
b
The New York Heart Association Classification provides a simple way of classifying the severity of heart failure. It categorizes patients in 1 of 4 classes based on their symptoms or limitations during physical exertion. Class I is least severe and class IV is most severe.