Table 2. Weighted-Average Subhazard Ratios of Major Risk Factors for Incident eGFR Less Than 60 mL/min/1.73 m2 in Cohorts With and Without Diabetes .
| Risk Factors | Subhazard Ratios (95% CI) for Incident eGFR <60 mL/min/1.73 m2 | |
|---|---|---|
| No Diabetes | With Diabetes | |
| Age, per 5 y | 1.29 (1.27-1.32) | 1.14 (1.13-1.15) |
| Women | 1.20 (1.18-1.22) | 1.15 (1.11-1.18) |
| Black race | 1.20 (1.13-1.27) | 1.10 (1.02-1.18) |
| eGFR 60-90, per –5 mL | 1.58 (1.57-1.59) | 1.43 (1.41-1.44) |
| eGFR ≥90, per –5 mL | 1.37 (1.34-1.41) | 1.16 (1.14-1.19) |
| History of CVD | 1.22 (1.18-1.26) | 1.21 (1.17-1.24) |
| Ever smoker | 1.13 (1.10-1.16) | 1.00 (0.96-1.04) |
| Hypertensiona | 1.43 (1.40-1.46) | 1.44 (1.39-1.50) |
| BMI, per 5 points | 1.07 (1.05-1.08) | 1.05 (1.04-1.07) |
| ACR, per 10-fold increase | 1.42 (1.37-1.48)b | 1.45 (1.42-1.49) |
| HbA1c (for oral diabetes medications), per 1% | 1.06 (1.05-1.07) | |
| Insulin vs oral diabetes medication (at 7% HbA1c) | 1.11 (1.05-1.19) | |
| None vs oral diabetes medication (at 7% HbA1c) | 0.86 (0.83-0.89) | |
| Interaction: HbA1c × insulin vs oral diabetes medication, per 1% | 1.02 (1.00-1.05) | |
| Interaction: HbA1c × no medications vs oral diabetes medication, per 1% | 1.04 (1.02-1.06) | |
| ACR missing indicator (set ACR = 10) | 0.96 (0.93-1.00) | |
Abbreviations: ACR, urine albumin:creatinine ratio; BMI, body mass index, calculated as weight in kilograms divided by height in meters squared; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c.
a
Defined as blood pressure of 140/90 mm Hg or the use of antihypertensive medications.
b
ACR was modeled using a patch in the nondiabetes model in which the coefficient for ACR was estimated in the population with available ACR with the other coefficients fixed. The model allows for prediction when ACR is missing. eTables 9 and 10 in the Supplement provide absolute risk and risk difference scenarios.