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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
The statistical distribution of the rotatable bonds of all analysed compounds (green = 3, compounds < 3 are in the lead-like space; yellow = 10, compounds < 10 are in the drug-like space; red = 17, compounds < 17 are in the known drug space. Total number of compounds = 179.