. 2019 Oct 31;24(21):3942. doi: 10.3390/molecules24213942

Table 1.

Definition of lead-like, drug-like and known drug space (KDS) in terms of molecular descriptors.

Molecular Descriptor	Lead-Like Space	Drug-Like Space	Known Drug Space
Molecular weight (g mol⁻¹)	300	500	800
Lipophilicity (Log P)	3	5	6.5
Hydrogen bond donors	3	5	7
Hydrogen bond acceptors	3	10	15
Polar surface area (Å²)	60	140	180
Rotatable bonds	3	10	17