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. 2019 Oct 31;24(21):3942. doi: 10.3390/molecules24213942

Table 4.

Compounds from Animalia and their inclusion within the defined chemical spaces.

Overall Lead-Like Space Drug-Like Space Known Drug Space
Molecular weight (g mol−1) 12.5% 58.7% 78.8%
Lipophilicity (Log P) 31.7% 61.5% 80.8%
Hydrogen bond donors 75.0% 84.6% 84.6%
Hydrogen bond acceptors 22.1% 75.0% 81.7%
Polar surface area (Å2) 31.7% 65.4% 82.7%
Rotatable bonds 12.5% 42.3% 71.2%
All criteria 1.0% 21.2% 54.8%