Table 3.
Correlation analysis between individual islet autoantibody and clinical features.
| GADA positive (n = 41) | IAA positive (n = 103) | ICA positive (n = 15) | |
|---|---|---|---|
| Age (years) | |||
| r | −0.018 | 0.020 | 0.042 |
| P | 0.700 | 0.666 | 0.354 |
| Gender (male/female) | |||
| r | −0.038 | −0.029 | 0.047 |
| P | 0.404 | 0.531 | 0.307 |
| BMI (kg/m2) | |||
| r | −0.167 | 0.009 | 0.025 |
| P | <0.0001a | 0.841 | 0.583 |
| WHR | |||
| r | −0.103 | 0.016 | 0.055 |
| P | 0.021b | 0.715 | 0.222 |
| Duration of diabetes (years) | |||
| r | 0.002 | 0.029 | −0.118 |
| P | 0.965 | 0.516 | 0.329 |
| Insulin treatment | |||
| r | 0.051 | 0.283 | −0.026 |
| P | 0.268 | <0.0001a | 0.569 |
| Diabetic family history | |||
| r | −0.006 | 0.012 | 0.010 |
| P | 0.888 | 0.785 | 0.820 |
| FBG (mmol/L) | |||
| r | 0.065 | 0.094 | −0.036 |
| P | 0.146 | 0.038b | 0.428 |
| HbA1C (%) | |||
| r | 0.049 | 0.040 | −0.007 |
| P | 0.285 | 0.390 | 0.876 |
| LDL-CH (mmol/L) | |||
| r | −0.040 | −0.004 | 0.010 |
| P | 0.378 | 0.379 | 0.824 |
| HDL-CH (mmol/L) | |||
| r | 0.033 | 0.185 | −0.020 |
| P | 0.470 | <0.0001a | 0.652 |
| TG (mmol/L) | |||
| r | −0.111 | −0.046 | −0.012 |
| P | 0.014b | 0.309 | 0.788 |
| TCHOL (mmol/L) | |||
| r | −0.053 | 0.062 | 0.011 |
| P | 0.238 | 0.171 | 0.812 |
| ALT (U/L) | |||
| r | 0.070 | 0.047 | −0.089 |
| P | 0.118 | 0.295 | 0.202 |
| AST (U/L) | |||
| r | −0.020 | 0.093 | −0.019 |
| P | 0.656 | 0.039b | 0.668 |
| AST/ALT | |||
| r | 0.002 | 0.035 | 0.079 |
| P | 0.967 | 0.431 | 0.078 |
| GGT (U/L) | |||
| r | −0.057 | 0.049 | 0.030 |
| P | 0.209 | 0.047b | 0.510 |
| Ucr (μmol/L) | |||
| r | −0.082 | −0.059 | −0.071 |
| P | 0.074 | 0.199 | 0.124 |
| UREA (mmol/L) | |||
| r | 0.074 | 0.023 | 0.016 |
| P | 0.100 | 0.603 | 0.727 |
| mALB (mg/L) | |||
| r | −0.122 | −0.051 | 0.024 |
| P | 0.007c | 0.262 | 0.605 |
| U-mALB/Ucr (mg/g) | |||
| r | −0.090 | 0.002 | 0.024 |
| P | 0.052 | 0.959 | 0.605 |
| CREA (μmol/L) | |||
| r | −0.045 | 0.001 | 0.078 |
| P | 0.323 | 0.974 | 0.683 |
| UA (μmol/L) | |||
| r | −0.085 | −0.062 | 0.056 |
| P | 0.059 | 0.168 | 0.210 |
Data of r and P values were calculated from Spearman correlation analysis. A P value <0.05 was considered as statistically significant. Significant correlations were in bold and the significance level is indicated with superscript letters.
aP < 0.0001, bP < 0.05 and cP < 0.01.
ALT, alanine aminotransferase; AST, aspartate transaminase; BMI, body mass index; CREA, serum creatinine; FBG, fasting blood glucose; GADA, glutamic acid decarboxylase autoantibodies; GGT, γ-glutamyltransferase; HbA1c, hemoglobin A1c; HDL-CH, high-density lipoprotein (cholesterol); IAA, insulin autoantibodies; ICA, islet cell cytoplasmic autoantibodies; LDL-CH, low-density lipoprotein (cholesterol); mALB, urinary microalbumin; TCHOL, total cholesterol; TG, triglycerides; UA, serum uric acid; Ucr, urine creatinine; WHR, waist-hip ratio.
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