Table 1.
Clinical characteristics of pediatric patients
| Patient (acute) | Age | Gender | Pain intensity (0–10) | Pain duration (months) | Site | Pain distribution | Medication (s) | Patient (chronic) | Age | Gender | Pain intensity (0–10) | Pain duration (months) | Site | Pain distribution | Medication (s) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 19 | M | 3.5 | 0.7 | R | Foot | ‐ | 17 | 17 | F | 7.0 | 3 | R | Leg, foot | Gabapentin |
| 2 | 19 | F | 2.0 | 0.6 | R | Foot | Salbutamol | 18 | 11 | M | 3.0 | 8 | L | Leg, foot | Gabapentincetalopramclonodine |
| 3 | 17 | F | 4.0 | 1.9 | R | Foot | ‐ | 19b | 15 | M | 7.0 | 12 | R | Knee, foot | Amitriptyline |
| 4 | 15 | F | 3.5 | 0.7 | L | Distal leg, foot | ‐ | 20 | 16 | F | 2.5 | 48 | L | Leg, foot | Doxepin |
| 5 | 12 | F | 4.0 | 0.8 | L | Foot | Salbutamol | 21 | 17 | F | 6.0 | 19 | L | Leg, foot | Pregabalin |
| 6 | 18 | M | 5.0 | 0.9 | R | Foot | ‐ | 22 | 14 | F | 7.5 | 3 | L | Leg, foot | Duloxetine |
| 7 | 22 | M | 4.5 | 0.6 | L | Foot | ‐ | 23 | 17 | F | 6.0 | 85 | R | Leg, foot | Gabapentin |
| 8a | 15 | M | 6.0 | 1.7 | L | Foot | ‐ | 24 | 13 | F | 5.5 | 13 | L | Leg, foot | Amitriptyline |
| 9 | 14 | M | 4.5 | 1.5 | L | Foot | ‐ | 25 | 10 | M | 7.0 | 5 | R | Leg, foot | Gabapentin |
| 10 | 15 | F | 4.0 | 1.4 | R | Foot | Montelukast | 26 | 15 | M | 4.0 | 11 | L | Knee | ‐ |
| 11 | 16 | F | 2.5 | 1.1 | R | Foot | ‐ | 27 | 14 | F | 3.5 | 3 | R | Thigh, leg, foot | ‐ |
| 12 | 15 | M | 5.5 | 1.0 | L | Foot | ‐ | 28 | 15 | F | 8.0 | 9 | L | Leg, foot | ‐ |
| 13 | 15 | F | 4.5 | 0.9 | R | Foot | ‐ | 29 | 15 | F | 7.0 | 10 | R | Leg, foot | Gabapentin |
| 14 | 12 | F | 4.5 | 0.9 | L | Foot | ‐ | 30 | 11 | M | 6.0 | 3 | L | Leg, foot | ‐ |
| 15 | 13 | F | 3.0 | 3.1 | R | Distal leg, foot | ‐ | 31 | 11 | M | 7.0 | 3 | R | Leg, foot | ‐ |
| 16 | 16 | F | 2.5 | 2.1 | R | Foot | Tetracycline lysine doxycycline | 32 | 17 | F | 5.5 | 6 | L | Foot |
Gabapentinibuprofin Doxepin |
| Acute mean ± SEM | 15.8 ± 0.6 | 3.97 ± 0.3 | 1.2 ± 0.2 | Chronic mean ± SEM | 14.3 ± 0.6 | 5.91 ± 0.5 | 15.0 ± 5.4 |
Abbreviations: F, female; L, left; M, male; R, right.
a
Removed from seed‐based connectivity analysis due to failed image acquisition.
b
Removed from seed‐based connectivity analysis due to excessive head motion. Note that brain images for all patients with unilateral left pain were flipped to the right.