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. 2019 Jul 30;40(16):4789–4800. doi: 10.1002/hbm.24737

Figure 4.

Figure 4

Temporal HMM characteristics. Red area: HC, blue area: MS(BZD−), green area: MS(BZD+). Red stars denote the significance of the permutation test MS(BZD+) > MS(BZD−) and blue stars of MS(BZD+) < MS(BZD−). No differences are observed between any of the two MS cohorts and the healthy control sample. *p < .05, **p < .01, ***p < .001 (uncorrected). MLT, mean lifetime; FO, fractional occupancy; Freq, frequency of occurrence; Int, mean interval between two consecutive occurrences. MS, multiple sclerosis; HMM, hidden Markov model; BZD, benzodiazepine [Color figure can be viewed at http://wileyonlinelibrary.com]