Table 3.
Total and regional brain volumes differences between CHD and controls
| Variables volumes in mm3 controlling for TBV and SES (SD) | CHD (n = 50) | Control (n = 48) | % difference | q value |
|---|---|---|---|---|
| TBV (105) | 12.13 (1.46) | 13.30 (1.19) | 8.80 | <0.001 |
| Total white matter (104) | 38.68 (6.02) | 44.70 (5.13) | 13.46 | 0.022 |
| Total cerebral gray matter (104) | 52.16 (5.86) | 56.28 (4.90) | 7.32 | 0.385 |
| Right CA1 | 679.87 (128.95) | 819.18 (93.96) | 17.01 | 0.002 |
| Right subiculum | 312.36 (61.65) | 370.71 (47.50) | 15.74 | 0.01 |
| Right CA4/DG | 493.49 (99.99) | 599.75 (67.86) | 17.72 | 0.001 |
| Right CA2/CA3 | 127.60 (28.94) | 153.81 (28.84) | 17.04 | 0.012 |
| Right stratuma | 420.57 (86.43) | 514.06 (69.64) | 18.19 | 0.001 |
| Left CA1 | 675.96 (129.39) | 797.38 (94.52) | 15.23 | 0.012 |
| Left subiculum | 279.06 (53.83) | 325.34 (38.30) | 14.23 | 0.044 |
| Left CA4/DG | 500.74 (101.23) | 620.97 (66.57) | 19.36 | <0.001 |
| Left CA2/CA3 | 130.15 (26.78) | 158.55 (27.30) | 17.91 | <0.001 |
| Left stratuma | 499.24 (98.32) | 598.78 (69.85) | 16.62 | 0.002 |
| Right fimbria | 108.33 (21.50) | 124.58 (15.15) | 13.04 | 0.061 |
| Left fimbria | 103.34 (18.63) | 122.06 (16.84) | 15.34 | 0.004 |
| Right fornix | 501.57 (97.50) | 606.23 (53.67) | 17.26 | <0.001 |
| Left fornix | 453.11 (79.66) | 537.46 (50.92) | 15.69 | <0.001 |
| Right alveus | 270.20 (47.70) | 309.24 (38.98) | 12.62 | 0.061 |
| Left alveus | 360.77 (64.26) | 413.37 (56.38) | 12.72 | 0.068 |
Abbreviations: CA, cornu ammonis; DG, dentate gyrus; SES, socioeconomic status; TBV, total brain volume.
a
Includes stratum radiatum/stratum lacunosum/stratum moleculare.