Table 2.
Mega‐analytical statistics comparing groups of individuals with schizophrenia and healthy controls using FC measures from resting‐state networks. ES values (in bold font) survived multiple comparison corrections (Bonferroni correction, p < .05)
| Seed‐based analysis approach | |||||
|---|---|---|---|---|---|
| Network | Connections | ES | 95% CI | z‐Value | p‐Value |
| AN | a1‐a2 | −0.54 | [−0.70; −0.37] | −6.35 | 2.2E‐10 |
| a2‐a1 | −0.51 | [−0.68; −0.34] | −6.04 | 1.5E‐09 | |
| AttN | f1‐p1 | −0.35 | [−0.51; −0.18] | −4.15 | 3.3E‐05 |
| p1‐f1 | −0.35 | [−0.51; −0.19] | −4.19 | 2.8E‐05 | |
| f2‐p2 | −0.25 | [−0.42; −0.09] | −3.03 | .0025 | |
| p2‐f2 | −0.28 | [−0.44; −0.11] | −3.33 | .0009 | |
| DMN | r1‐r2 | −0.25 | [−0.41; −0.08] | −2.97 | .0030 |
| r2‐r3 | −0.23 | [−0.39; −0.06] | −2.71 | .0067 | |
| r3‐r1 | −0.27 | [−0.43; −0.10] | −3.18 | .0015 | |
| r2‐r1 | −0.21 | [−0.37; −0.05] | −2.51 | 0122 | |
| r3‐r2 | −0.19 | [−0.36; −0.03] | −2.34 | .0192 | |
| r1‐r3 | −0.27 | [−0.44; −0.11] | −3.29 | .0010 | |
| ECN | r1‐r2 | −0.37 | [−0.54; −0.21] | −4.46 | 8.1E‐06 |
| r2‐r1 | −0.21 | [−0.38; −0.05] | −2.57 | .0101 | |
| FPN | f1‐p1 | −0.24 | [−0.40; −0.08] | −2.86 | .0042 |
| p1‐f1 | −0.20 | [−0.36; −0.03] | −2.37 | .0178 | |
| f2‐p2 | −0.24 | [−0.41; −0.08] | −2.94 | .0033 | |
| p2‐f2 | −0.22 | [−0.38; −0.06] | −2.64 | .0084 | |
| SN | r1‐r2 | −0.46 | [−0.62; −0.29] | −5.46 | 4.7E‐08 |
| r2‐r3 | −0.40 | [−0.56; −0.23] | −4.75 | 2.1E‐06 | |
| r3‐r1 | −0.42 | [−0.58; −0.25] | −4.97 | 6.8E‐07 | |
| r2‐r1 | −0.49 | [−0.65; −0.32] | −5.76 | 8.2E‐09 | |
| r3‐r2 | −0.39 | [−0.55; −0.22] | −4.63 | 3.6E‐06 | |
| r1‐r3 | −0.43 | [−0.60; −0.27] | −5.15 | 2.6E‐07 | |
| SMN | m1‐m2 | −0.29 | [−0.45; −0.12] | −3.40 | .0007 |
| m2‐m3 | −0.26 | [−0.42; −0.10] | −3.11 | .0019 | |
| m3‐m1 | −0.35 | [−0.52; −0.19] | −4.21 | 2.6E‐05 | |
| m2‐m1 | −0.35 | [−0.51; −0.18] | −4.16 | 3.1E‐05 | |
| m3‐m2 | −0.21 | [−0.38; −0.05] | −2.55 | .0107 | |
| m1‐m3 | −0.33 | [−0.49; −0.16] | −3.91 | 9.3E‐05 | |
| VN | v1‐v2 | −0.27 | [−0.44; −0.11] | −3.27 | .0011 |
| v2‐v3 | −0.29 | [−0.46; −0.13] | −3.51 | .0005 | |
| v3‐v1 | −0.20 | [−0.37; −0.04] | −2.45 | .0144 | |
| v2‐v1 | −0.21 | [−0.38; −0.05] | −2.56 | .0106 | |
| v3‐v2 | −0.29 | [−0.45; −0.13] | −3.46 | .0005 | |
| v1‐v3 | −0.25 | [−0.42; −0.09] | −3.04 | .0024 | |
| Mean ES | −0.31 | [−0.33; −0.28] | −19.5 | <1.0E‐04 | |
Abbreviations: AN, auditory network, a1/a2, left/right primary and association auditory cortices; AttN, , attention network, f1/f2, left/right middle frontal gyrus, and p1/p2, left/right superior parietal lobule; DMN, default mode network, r1, posterior cingulate/precuneus, r2, bilateral temporal–parietal regions and, r3, ventromedial frontal cortex; ECN, executive control network, r1, anterior cingulate cortex and r2, bilateral medial frontal gyrus; ES, effect size; FC, functional connectivity; FPN, frontoparietal network, f1/f2, left/right frontal area (inferior frontal gyrus) and p1/p2, left/right parietal area (inferior parietal lobule); SN, salience network, r1, anterior cingulate cortex and r2/r3, left/right insula; SMN, sensorimotor network, m1/m3, left/right motor area and m2, supplementary motor area; and VN, visual network, v1, medial visual areas, v2, occipital visual areas, and v3, lateral visual areas.