Table 1.

The associations between neocortex 5‐HT_2AR binding and trait Openness

Predictors	Beta	SE	p‐Value	95% CI	Stand. Beta
Model 1	[18F]altanserin, n = 139
Neocortex 2A binding	−2.54	3.75	0.50	−9.95, 4.88	−0.068
Age	−0.43	0.11	0.000078	−0.64, −0.22	−0.40
Sex	−4.32	3.14	0.17	−10.53, 1.89	−0.11
Model 2	[11C]‐Cimbi‐36, n = 28
Neocortex 2A binding	9.03	29.72	0.76	−52.31, 70.37	0.097
Age	1.02	0.26	0.31	−0.99, 3.03	0.26
Sex	−8.81	10.36	0.40	−30.20, 12.57	−0.22
Model 3	Combined [18F]altanserin and [11C]‐Cimbi‐36, n = 159
Neocortex 2A binding	−2.92	3.50	0.40	−9.79, 3.94	−0.07
Age	−0.42	0.10	0.000020	−0.62, −0.23	−0.38
Radioligand	−9.55	4.46	0.032	−18.30, −0.81	−0.19
Sex	−5.24	3.06	0.087	−11.24, 0.77	−0.14

Note. Parameters from the models used to investigate associations between neocortex 5‐HT_2AR binding and trait Openness, including the combined model with both radioligands, [18F]altanserin and [11C]‐Cimbi‐36, in Model 3. Combined analyses included 167 observations (eight individuals scanned two times). Sex parameter estimates reflect difference in trait Openness relative to female. SE = standard error, 95% CI = 95% confidence interval, Stand. Beta = standardized regression coefficient.