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. 2019 Oct 8;18(6):6046–6056. doi: 10.3892/ol.2019.10970

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — CDK9 is associated with anti-inflammatory molecules in CRC. (A) Correlations of CDK9 with TGFB1 and SMAD4 mRNA expression in CRC. (B) Co-expression analysis of CDK9, TGFB1 and SMAD4 proteins. (C) Correlation of CDK9 with BRAF mRNA expression in CRC. (D) Influence of the BRAF mutation on CD8⁺ T cell infiltration in colon cancer. (E) Influence of the BRAF mutation on B cell infiltration in colon cancer. (F) Influence of the BRAF mutation on dentritic cell infiltration in colon cancer. (G) Influence of the BRAF mutation on dendritic cells infiltration in rectal cancer. Scatter plots are presented to show the distributions of each immune subset at each somatic copy number status for BRAF in colorectal cancer. The infiltration level for each category was compared with the diploid/normal group using one-way ANOVA followed by Tukey's multiple comparison test. *P<0.05, **P<0.001 vs. normal. CRC, colorectal cancer; CDK9, cyclin-dependent kinase 9; TGFB1, transforming growth factor ß1; SMAD4, SMAD family member 4; TPM, transcripts per million; COAD, colon adenocarcinoma; READ, rectum adenocarcinoma.