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. 2019 Oct 9;18(6):5930–5940. doi: 10.3892/ol.2019.10972

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Copyright: © Zou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — JMJD3 regulates the expression levels of CXCL12. (A) mRNA expression levels of CXCL12 and its receptor CXCR4 in U-251MG (left panel) and U-87MG ATCC (right panel) cells in which JMJD3 was overexpressed or depleted. (B) Western blotting results revealing CXCL12, CXCR4 and H3K27me3 protein expression in U-251MG (left panel) and U-87MG ATCC (right panel) cells in which JMJD3 was overexpressed or depleted. (C) Relative protein expression of CXCL12, CXCR4 and H3K27me3 was determined in U-251MG (left panel) and U-87MG ATCC (right panel) cells. β-actin was used as an endogenous control. **P<0.01. ATCC, American Type Culture Collection; CXCL12, C-X-C motif chemokine ligand 12; CXCR4, C-X-C motif chemokine receptor 4; H3K27me3, histone H3 lysine 27 trimethyl; JMJD3, Jumonji domain-containing protein 3; shRNA, short hairpin RNA.