Table II.

Functional roles of the 10 hub genes with degree of connectivity ≥10.

No.	Gene symbol	Full name	Function
1	TOP2A	DNA Topoisomerase II α	Target for anticancer agents; mutations are associated with drug resistance
2	PAICS	Phosphoribosylaminoimidazole carboxylase	Involved in de novo synthesis of purine nucleotides
3	CDK1	Cyclin-dependent kinase 1	Regulates cell cycle progression, apoptosis and carcinogenesis of tumour cells
4	CKS2	CDC28 protein kinase regulatory subunit 2	Binds to the catalytic subunit of cyclin-dependent kinases; essential for their biological function
5	CKAP2	Cytoskeleton associated protein 2	Possesses microtubule stabilizing properties; involved in regulating aneuploidy, cell cycle and cell death in a p53/TP53-dependent manner
6	CEP55	Centrosomal protein 55	Promotes the proliferation of lung, breast and thyroid cancer
7	VEGFA	Vascular endothelial growth factor A	Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces blood vessel permeabilization
8	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2	Regulates Akt and PKC signalling.
9	RRM2	Ribonucleotide reductase M2 polypeptide	Catalyses the biosynthesis of deoxyribonucleotides; inhibits Wnt signalling
10	NEK2	NIMA (never in mitosis gene a)-related kinase 2	Involved in the regulation of mitosis