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. 2019 Oct 11;18(6):6117–6125. doi: 10.3892/ol.2019.10980

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Shi induces autophagy and reduces YAP expression in HCT116 and SW620 cells. The expression LC3-II and p62 were determined using western blot analysis in (A) HCT116 and (B) SW620 cells treated with an increasing concentration of Shi for 24 h and in (C) HCT116 and (D) SW620 cells treated with 10 µM Shi for 6, 12 and 24 h. YAP and p-YAP expression was determined using western blot analysis in (E) HCT116. YAP and p-YAP expression was determined using western blot analysis. (F) SW620 cells treated with an increasing concentration of Shi for 24 h and in (G) HCT116 and (H) SW620 cells treated with 10 µM Shi for 6, 12 and 24 h. *P<0.05, **P<0.01, compared with control. Shi, shikonin; p, phosphorylated; YAP, yes-associated protein.

Figure 3. — Shi induces autophagy and reduces YAP expression in HCT116 and SW620 cells. The expression LC3-II and p62 were determined using western blot analysis in (A) HCT116 and (B) SW620 cells treated with an increasing concentration of Shi for 24 h and in (C) HCT116 and (D) SW620 cells treated with 10 µM Shi for 6, 12 and 24 h. YAP and p-YAP expression was determined using western blot analysis in (E) HCT116. YAP and p-YAP expression was determined using western blot analysis. (F) SW620 cells treated with an increasing concentration of Shi for 24 h and in (G) HCT116 and (H) SW620 cells treated with 10 µM Shi for 6, 12 and 24 h. *P<0.05, **P<0.01, compared with control. Shi, shikonin; p, phosphorylated; YAP, yes-associated protein.