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. 2019 Oct 11;18(6):6117–6125. doi: 10.3892/ol.2019.10980

Figure 5.

Figure 5.

Knockdown of YAP increases sensitivity of HCT116 and SW620 cells to Shi. The effect of YAP downregulation in combination with 10 µM Shi on (A) HCT116 and (B) SW620 cell growth. YAP, LC3-II and p62 protein expression was measured using western blot analysis in (C) HCT116 and (D) SW620 cells transfected with YAP siRNA and treated with Shi. (E-H) Densitometry analysis of LC3-II, p62 and YAP. *P<0.05, compared with control. #P<0.05, compared with YAP siRNA transfection. Shi, shikonin; YAP, yes-associated protein.