Table I.
Clinical characteristics of the training set.
| OS, months | OS, % | |||||
|---|---|---|---|---|---|---|
| Characteristic | No. of patients | Median | 95% CI | 3-year | 5-year | Log-rank P-value |
| Age | ||||||
| ≤60 | 2,360 | 34 | 30.61–37.39 | 48.5±1.2 | 39.4±1.4 | <0.001 |
| >60 | 8,384 | 21 | 21.13–21.87 | 35.8±0.6 | 25.4±0.7 | |
| Sex | ||||||
| Male | 5,929 | 19 | 18.06–19.94 | 34.1±0.7 | 25.9±0.8 | <0.001 |
| Female | 4,815 | 29 | 27.22–30.78 | 43.3±0.9 | 31.7±1.0 | |
| Marital status | ||||||
| Married | 5,896 | 25 | 23.67–26.33 | 34.1±0.7 | 25.3±0.9 | <0.001 |
| Unmarried | 4,848 | 21 | 19.83–22.16 | 36.1±0.8 | 25.0±1.0 | |
| Race | ||||||
| Caucasian | 8,623 | 25 | 23.67–26.33 | 37.7±0.6 | 28.2±0.7 | <0.001 |
| African-American | 1,274 | 21 | 19.83–22.17 | 39.7±1.6 | 27.1±2.0 | |
| Other | 847 | 23 | 22.15–23.87 | 46.2±2.1 | 34.3±2.4 | |
| Histology | ||||||
| ADC | 5,552 | 32 | 30.17–33.83 | 46.1±0.8 | 33.9±1.0 | <0.001 |
| SCC | 4,784 | 16 | 15.12–16.87 | 29.6±0.8 | 22.2±0.9 | |
| LCC | 270 | 22 | 17.86–26.14 | 37.0±3.5 | 26.8±4.2 | |
| ASC | 138 | 17 | 13.13–20.87 | 78.4±3.6 | 61.2±4.3 | |
| Grade | ||||||
| I | 765 | 31 | 26.10–35.89 | 46.4±2.2 | 30.2±2.9 | <0.001 |
| II | 4,379 | 26 | 24.43–27.56 | 41.6±0.9 | 31.1±1.0 | |
| III | 5,441 | 20 | 18.96–21.04 | 35.3±0.8 | 26.2±0.9 | |
| IV | 159 | 17 | 12.84–21.16 | 34.7±4.3 | 29.8±4.6 | |
| AJCC (7th) T stage (45) | ||||||
| T1 | 1,324 | 32 | 27.81–36.20 | 47.1±1.6 | 34.2±2.1 | <0.001 |
| T2 | 3,996 | 27 | 25.24–28.76 | 42.0±0.9 | 31.0±1.1 | |
| T3 | 3,419 | 23 | 21.53–24.47 | 38.5±1.0 | 29.3±1.1 | |
| T4 | 2,005 | 14 | 12.90–15.10 | 26.3±1.2 | 17.9±1.3 | |
| AJCC (7th) N stage (45) | ||||||
| N0 | 3,362 | 29 | 26.56–31.44 | 45.3±1.0 | 34.2±1.2 | <0.001 |
| N1 | 2,293 | 35 | 31.84–38.16 | 48.6±1.3 | 36.9±1.5 | |
| N2 | 4,323 | 18 | 17.03–18.97 | 31.1±0.8 | 21.9±0.9 | |
| N3 | 766 | 13 | 11.91–14.08 | 22.0±1.8 | 13.8±2.0 | |
| Primary site | ||||||
| Main bronchus | 302 | 12 | 9.78–14.21 | 33.9±0.9 | 25.4±1.0 | <0.001 |
| Upper lobe | 6,650 | 24 | 22.86–25.13 | 39.4±0.7 | 30.2±0.8 | |
| Middle lobe | 460 | 28 | 23.24–32.76 | 43.6±2.8 | 31.9±3.4 | |
| Lower lobe | 3,332 | 23 | 21.49–24.51 | 37.9±1.0 | 26.6±1.2 | |
| Laterality | ||||||
| Left | 4,448 | 23 | 21.64–24.37 | 38.9±0.9 | 29.4±1.0 | 0.346 |
| Right | 6,296 | 23 | 21.85–24.15 | 38.5±0.7 | 27.9±0.8 | |
| Surgery | ||||||
| None | 5,757 | 13 | 12.49–13.51 | 20.2±0.7 | 12.2±0.7 | <0.001 |
| Wedge resection | 351 | 30 | 24.78–35.22 | 45.9±3.2 | 35.6±3.7 | |
| Segmental resection | 114 | 41 | 28.39–53.61 | 52.5±5.9 | 37.6±7.2 | |
| Lobectomy | 4,522 | 56 | 51.17–60.83 | 60.4±0.9 | 47.9±1.1 | |
| Lymph node dissection | ||||||
| None | 5,652 | 13 | 12.49–13.51 | 20.2±0.7 | 12.2±0.7 | <0.001 |
| 1–3 | 651 | 40 | 33.07–46.93 | 45.9±3.2 | 35.6±3.7 | |
| ≥4 | 4,441 | 53 | 48.87–23.87 | 60.4±0.9 | 47.9±1.1 | |
| Radiation | ||||||
| No | 5,152 | 19 | 18.17–19.83 | 33.9±0.9 | 25.4±1.0 | <0.001 |
| Yes | 5,592 | 29 | 27.12–30.88 | 45.1±0.8 | 35.5±0.9 | |
| Chemotherapy | ||||||
| No | 4,185 | 18 | 16.81–19.19 | 33.9±0.9 | 25.4±1.0 | <0.001 |
| Yes | 6,559 | 27 | 25.73–28.27 | 41.6±0.7 | 30.5±0.9 | |
OS, overall survival; ADC, adenocarcinoma; SCC, squamous cell carcinoma; LCC, large cell carcinoma; ASC, adenosquamous carcinoma; AJCC (7th), American Joint Committee on Cancer.