Figure 1.

Scatterplots of the statistical trends between subcortical regional PiB retention values and normalized subcortical overall volumes and hippocampal subfields volumes in cognitively normal individuals. Correlations uncorrected for multiple comparisons were found between subcortical regional PiB retention values and normalized subcortical overall volumes, namely, a positive relationship with the left hippocampus and a negative relationship with the right putamen (a). Correlations uncorrected for multiple comparisons were also found with normalized hippocampal subfields volumes, namely with the left CA1 subfield, subiculum, and molecular layer (b). An example of segmentation of the CA1 subfield, the subiculum, and the molecular layer from one individual from our cohort is also presented (c). CA, cornu ammonis; PiB, Pittsburgh Compound B; SUVr, standardized uptake value ratio [Color figure can be viewed at http://wileyonlinelibrary.com]