Table 3.

Associations between amyloid accumulation in subcortical structures and subcortical surface using shape considering volume and shape only analyses in cognitively normal individuals

Clusters associated with regional PiB retention	Hemisphere	Number of vertices	MNI152 coordinates			F value	r value	p value
			x	y	z
Shape considering volume analyses
Hippocampus	Left	999	−33	−34	−9	22.2	.442	<.001
Hippocampus	Right	259	24	−14	−27	10.1	.376	<.001
		187	33	−32	−6	10.6	.299	.002
Thalamus	Left	2,752	−3	−13	−3	17.4	.351	<.001
Thalamus	Right	2,225	22	−32	−4	17.0	.331	.001
Pallidum	Right	285	22	−1	3	11.3	.255	.010
		109	17	−7	−6	15.4	.331	.001
Shape only analyses
Thalamus	Left	162	−4	−26	4	13.9	−.321	.001
		66	−5	−9	15	11.3	.310	.002
Thalamus	Right	576	6	−27	0	20.7	−.389	<.001
		199	8	−7	15	10.6	.299	.002
Pallidum	Right	44	17	−6	−6	14.7	.359	<.001

Note. Results are corrected for multiple comparisons using threshold‐free cluster enhancement and clusters were considered significant if below a statistical threshold of p < .05 using TFCE. Only clusters comprising at least 30 vertices are reported.

Abbreviations: MNI, Montreal Neurological Institute; PiB, Pittsburgh compound B; TFCE, threshold‐free cluster enhancement.