Differences in default mode network connectivity (mPFC seed) between the typically developing control and Down's syndrome groups, showing (a) controls > Down's syndrome (all), and (b) Down's syndrome (all) > typically developing controls. Where prefixed to the abbreviation of a brain region, L and R indicate the left and right hemisphere, respectively. ACG, anterior cingulate gyrus; CAL, calcarine cortex; CER9, region 9 of the cerebellum; CER7b, region 7 of the cerebellum; IFG, inferior frontal gyrus; IOG, inferior occipital gyrus; ITG, inferior temporal gyrus; MFG, inferior/middle frontal gyrus; MTG, middle temporal gyrus; PAL, pallidum; PCG, posterior cingulate gyrus; PCUN, precuneus; PreCG, precentral gyrus; SFGmed, medial superior frontal gyrus; SMA, supplementary motor area; SMG, supramarginal gyrus; SPG, superior parietal gyrus [Color figure can be viewed at http://wileyonlinelibrary.com]