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Inhibition of miR-221-5p expression activates the PI3K/AKT/mTOR signaling pathway. The expression levels of key proteins of the PI3K/AKT/mTOR pathway were detected using western blotting following transfection of myeloma bone disease mesenchymal stem cells with microRNA-221-5p inhibitor. *P<0.05, **P<0.01 vs. NC. AKT, protein kinase B; mTOR, mammalian target of rapamycin; NC, negative control; P-, phosphorylated; PI3K, phosphoinositide 3-kinase.
