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. 2019 Oct 10;18(6):5793–5800. doi: 10.3892/ol.2019.10975

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Copyright: © Yoshida et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Apoptosis assay in tumor xenografts in response to celecoxib with/without LPS-treatment. (A) Representative microphotographs of TUNEL staining in each group. Scale bar, 50 µm. (B) Apoptosis index by TUNEL staining. Each bar represents the mean ratio of the number of TUNEL-positive cells to the total number of tumor cells ± standard deviation. The apoptosis indices in the celecoxib-treated and LPS + celecoxib-treated group were significantly higher than those in the control and LPS-treated group, whereas the apoptosis indices in the LPS + celecoxib-treated group were significantly lower compared with those in the celecoxib-treated group. (C) Representative microphotographs of non-tumor tissues in TUNEL staining. Apoptosis was not induced in non-tumor tissues exposed to celecoxib treatment. Scale bar, 50 µm. **P<0.01 vs. control or LPS-treated group. LPS, lipopolysaccharide; TUNEL, terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling.