Table 3. Cox Multivariable Regression Models for Patients With 1 Year or More of Follow-up.
| Variable | Overall Composite Outcome | HF Composite Outcome | Atrial Fibrillation | Ventricular Arrhythmia Composite Outcome | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | |
| BMIa | ||||||||
| Preobesity vs normal weight | 1.102 (0.920-1.322) | <.001 | 1.192 (0.930-1.530) | <.001 | 1.067 (0.846-1.345) | .006 | NA | NA |
| Obesity vs normal weight | 1.634 (1.332-1.919) | 1.885 (1.485-2.393) | 1.416 (1.115-1.798) | NA | NA | |||
| Age at diagnosis (per y increase) | 1.038 (1.032-1.043) | <.001 | 1.034 (1.027-1.041) | <.001 | 1.039 (1.031-1.046) | <.001 | 1.019 (1.001-1.038) | .04 |
| Sex (men vs women) | 0.808 (0.700-0.931) | .003 | 0.609 (0.506-0.732) | <.001 | NA | NA | NA | NA |
| Race (white vs nonwhite) | 0.927 (0.771-1.115) | .42 | NA | NA | NA | NA | NA | NA |
| LAD | 1.021 (1.014-1.027) | <.001 | 1.024 (1.016-1.032) | <.001 | 1.026 (1.018-1.034) | <.001 | 1.032 (1.011-1.053) | .003 |
| Obstruction (yes vs no)b | 1.554 (1.345-1.795) | <.001 | 1.894 (1.548-2.224) | <.001 | 1.286 (1.060-1.560) | .01 | NA | NA |
Abbreviations: BMI, body mass index; HF, heart failure; HR, hazard ratio; LAD, left atrial diameter; NA, not applicable.
a
Calculated as weight in kilograms divided by height in meters squared. Normal weight defined as a BMI less than 25; preobesity, a BMI from 25 to 30; and obesity, a BMI greater than 30.
b
Defined as a left ventricular outflow tract gradient greater than 30 mm Hg.