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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Nature. 2019 May 1;570(7761):332–337. doi: 10.1038/s41586-019-1195-2

Fig. 3 |. Cellular subpopulation trait associations.

Fig. 3 |

a–d, Overrepresentation (hypergeometric test) within each sub-cluster of cells isolated from individuals with varying (a) amyloid levels, (b) Braak stages, (c) cognitive status at time of death (cogdx, 1=no impairment; 4=impairment), and (d) sex. Only significant associations after FDR correction over all variables and subpopulations are displayed. e, Fraction of cells in each sub-cluster. f, Quantitative clinico-pathological feature enrichment across sub-clusters for: global AD pathology burden (gpath); neurofibrillary tangle burden (nft); neuritic plaque count (plaq_n); overall amyloid levels (amyloid); global cognitive function (global_cogn). Z-score estimated using resampling. Square size proportional to numeric entry. g, Immunohistochemistry with anti-OLIG2 (red) and anti-CRYAB (green) antibodies in white matter of Brodmann area 10 of a no-pathology and an AD-pathology individual (scale bar: 10μm). The experiment was performed once. h, Similar to (g) for anti-OLIG2 (red) and anti-QDPR (green). The experiment was performed once.