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. 2019 Oct 18;18(6):6775–6780. doi: 10.3892/ol.2019.11001

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Figure 4. — lncRNA HAND2-AS1 overexpression inhibits RUNX2 expression. (A) lncRNA HAND2-AS1 transfection mediated a significant downregulation in RUNX2 expression in MDA-MB-231 and BT-20 TNBC breast cancer cells, whilst (B) RUNX2 transfection had no significant effects on lncRNA HAND2-AS1 expression. (C) No significant differences in the expression levels of HAND2-AS1 and RUNX2 were observed between the two cell lines. *P<0.05. lncRNA HAND2-AS1, long non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1; RUNX2, runt-related transcription factor 2; C, control; NC, negative control.