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Effect of CLDN1 silencing on the motility of Hep/5FU cells. Hep/5FU cells were transfected with negative control or siCLDN1 and cultured in the presence or absence of 50 mg/l 5-FU for 48 h. (A) Migration and (B) invasion were evaluated. Data are presented as the mean ± SEM of three independent experiments. **P<0.01. NS, no significance; CLDN1, claudin-1; Hep/5FU, 5-fluorouracil-resistant HepG2; siCLDN1, small interfering RNA targeting claudin-1.
