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. 2019 Oct 4;18(6):5717–5724. doi: 10.3892/ol.2019.10964

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Measurements of the expanded population percentages of various cytokine-induced killer cell groups during ex vivo culture. Six sub-groups are presented according to T cell subtypes. (A-F) Changes in the proportion of (A) CD3⁺, CD3⁺CD4⁺ and CD3⁺CD8⁺; (B) CD3⁻CD16⁺CD56⁺, CD3⁺CD16⁺CD56⁺ and CD19⁺; (C) Tregs; (D) CD8⁺CD28⁻ and CD8⁺CD28⁺; (E) CD4⁺TIM-3⁺, CD4⁺LAG-3⁺ and CD4⁺4-1BB⁺; and (F) CD8⁺LAG-3⁺, CD8⁺4-1BB⁺ and CD8⁺TIM-3⁺. Multiple subgroup comparisons were performed using ANOVA. *P<0.05 vs. day 0; ^#P<0.05 vs. day 15. IFN-γ, interferon-γ; TNF-α, tumor necrosis factor-α; IL-2, interleukin-2; LAG-3, lymphocyte-activation gene 3; 4-1BB, tumor necrosis factor receptor superfamily member 9; TIM-3, T cell immunoglobulin and mucin protein 3.

Figure 2. — Measurements of the expanded population percentages of various cytokine-induced killer cell groups during ex vivo culture. Six sub-groups are presented according to T cell subtypes. (A-F) Changes in the proportion of (A) CD3⁺, CD3⁺CD4⁺ and CD3⁺CD8⁺; (B) CD3⁻CD16⁺CD56⁺, CD3⁺CD16⁺CD56⁺ and CD19⁺; (C) Tregs; (D) CD8⁺CD28⁻ and CD8⁺CD28⁺; (E) CD4⁺TIM-3⁺, CD4⁺LAG-3⁺ and CD4⁺4-1BB⁺; and (F) CD8⁺LAG-3⁺, CD8⁺4-1BB⁺ and CD8⁺TIM-3⁺. Multiple subgroup comparisons were performed using ANOVA. *P<0.05 vs. day 0; ^#P<0.05 vs. day 15. IFN-γ, interferon-γ; TNF-α, tumor necrosis factor-α; IL-2, interleukin-2; LAG-3, lymphocyte-activation gene 3; 4-1BB, tumor necrosis factor receptor superfamily member 9; TIM-3, T cell immunoglobulin and mucin protein 3.