Ciancio 1995

Methods	Randomised, parallel group study. Patients and outcome assessor blind. No withdrawals.
Participants	Adults. Age 35 to 65 years. 20 enrolled and results given for 20.
Interventions	2 groups. Antiseptic mouthwash (20 ml Listerine) rinse twice per day for 30 seconds versus placebo (5% hydroalcohol). Recall every month. Study duration: 3 months.
Outcomes	Turesky modification of Quigley‐Hein plaque index, a modification of the Ainamo and Bay bleeding index, probing attachment levels (mm), probing pocket depth (mm) at 1, 2, 3 months. 3‐month data used.
Notes	The Ainamo and Bay bleeding index was recorded using a "sweeping motion" and not with a "gentle probing".
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"Subjects were then assigned by a computer‐ generate random code to one of two mouthrinse groups".
Allocation concealment (selection bias)	Low risk	"All mouthrinse bottles were coded and neither the examiner, individual dispensing mouthrinses, nor subjects were aware of treatment code".
Blinding (performance bias and detection bias) All outcomes	Low risk	"All mouthrinse bottles were coded and neither the examiner, individual dispensing mouthrinses, nor subjects were aware of treatment code".
Incomplete outcome data (attrition bias) All outcomes	Low risk	All data reported. No loss to follow‐up.
Selective reporting (reporting bias)	Low risk	All data reported.
Other bias	Low risk
Blinding of the patient?	Low risk	"All mouthrinse bottle were coded and neither the examiner, individual dispensing mouthrinses, nor subjects were aware of treatment code".