Table 2.
Plasma folate, cobalamin, holoTC and tHcy status at preconception, in the cord and in the mother and 6 year old child according to preconception tHcy category
| Moderately elevated (tHcy ≥ 9.04 µmol/L) | n | Normal (tHcy < 9.04 µmol/L) | N | P | d a | |
|---|---|---|---|---|---|---|
| Preconception | ||||||
| Plasma folate (nmol/L) | 6.0 (3.5, 10.4)b | 20 | 9.7 (7.7, 12.2) | 49 | 0.44c | 0.41 |
| Plasma cobalamin (pmol/L) | 399 (310, 512) | 21 | 379 (332, 432) | 50 | 1.00 | 0.10 |
| Plasma holoTC (pmol/L) | 56.9 (46.8, 69.3) | 18 | 68.3 (60.4, 77.2) | 29 | 0.36 | 0.52 |
| tHcy (µmol/L) | 11.2 (10.3, 12.2) | 23 | 7.2 (6.8, 7.6) | 51 | <0.001 | 2.19 |
| Cord | ||||||
| Plasma folate (nmol/L) | 40.5 (30.5, 53.7) | 18 | 45.5 (39.1, 53.0) | 43 | 1.00 | 0.21 |
| Plasma cobalamin (pmol/L) | 489 (377, 635) | 20 | 431 (358, 519) | 48 | 1.00 | 0.19 |
| Plasma holoTC (pmol/L) | 72.8 (43.6, 121.7) | 9 | 108.9 (77.5, 152.9) | 11 | 0.57 | 0.72 |
| tHcy (µmol/L) | 7.0 (5.8, 8.3) | 21 | 5.2 (4.8, 5.7) | 48 | 0.008 | 0.81 |
| Mother (6 years after birth) | ||||||
| Plasma folate (nmol/L) | 3.5 (2.9, 4.4) | 23 | 5.4 (4.7, 6.3) | 51 | 0.008 | 0.77 |
| Plasma cobalamin (pmol/L) | 365 (305, 437) | 21 | 398 (362, 438) | 49 | 1.00 | 0.23 |
| Plasma holoTC (pmol/L) | 104.4 (85.0, 128.2) | 19 | 107.1 (94.2, 121.8) | 48 | 0.91 | 0.32 |
| tHcy (µmol/L) | 10.1 (9.2, 11.0) | 21 | 7.55 (7.06, 8.06) | 52 | <0.001 | 1.18 |
| Child (age 6) | ||||||
| Plasma folate (nmol/L) | 5.6 (4.3, 7.4) | 20 | 7.7 (6.8, 8.9) | 50 | 0.09 | 0.57 |
| Plasma cobalamin (pmol/L) | 672 (582, 775) | 24 | 663 (607, 724) | 50 | 1.00 | 0.04 |
| Plasma holoTC (pmol/L) | 66.9 (56.7, 78.9) | 19 | 74.0 (67.9, 80.6) | 41 | 1.00 | 0.05 |
| tHcy (µmol/L) | 6.1 (5.7, 6.6) | 24 | 5.68 (5.34, 6.04) | 50 | 0.60 | 0.34 |
a
Cohen's d effect size.
b
Values are geometric mean (95% CI).
c
Student's unpaired T‐test compared to low‐mid category, with post‐hoc Bonferroni correction for multiple comparisons.