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. Author manuscript; available in PMC: 2020 Sep 19.
Published in final edited form as: Cell Chem Biol. 2019 Jul 11;26(9):1315–1321.e3. doi: 10.1016/j.chembiol.2019.06.006

Figure 4. WES of MLN4924 resistant clones uncovers recurrent compound-resistant alleles in UBA3.

Figure 4.

(A) Cell Titer Glo assay of MLN4924 10-point DRC for parental A673-M1 cells and MLN4924-resistant clones A, C, D, E, F, and H. Data are represented as mean ± SD. (B) Table showing EC50 for MLN4924 from parental A673-M1 and each resistant clone. (C) UBA3 is the only gene mutated in all six clones. (D) UBA3 mutations identified in MLN4924-resistant clones. DRC, dose response curve.