Table 2.
Resting‐state functional connectivity of the anterior cerebellum (lobules IV–V). (a) Results from the full factorial ANOVA; (b) between‐group comparisons results; (c) correlation with symptoms results
| a) Full factorial ANOVA | Peak MNI coordinate | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| L/R | Brain region | k | Z | p | x | y | z | ||
| Main effect of group | R | Middle temporal gyrus | 314 | 6.16 | <.001 | 66 | −40 | −4 | |
| R | Angular & supramarginal gyri/TPJ | 314/subcluster | 5.23 | <.001 | 66 | −28 | 26 | ||
| Main effect of hemisphere | L | Anterior vermis/Lobule V | 1,147 | Inf | <.001 | −8 | −46 | −12 | |
| L/R | Posterior Cingulum | 470 | 4.18 | <.001 | −2 | −34 | 40 | ||
| R | Middle cingulum/SMA | 470/subcluster | 4.01 | <.001 | 8 | −4 | 50 | ||
| Group × hemisphere interaction effect | R | Medial superior frontal gyrus/SMA | 501 | 3.92 | <0.001 | 4 | 28 | 46 | |
| (b) Between‐group comparisons | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Peak MNI coordinate | |||||||||
| Seed region | Comparison | L/R | Brain region | k | Z | p | x | y | z |
| Left lobules IV–V | HC>PTSD | ns | |||||||
| PTSD>HC | R | Fusiform gyrus | 573 | 4.26 | <.001 | 28 | −40 | −14 | |
| R | Hippocampus | 573/subcluster | 4.09 | <.001 | 38 | −28 | −6 | ||
| HC>PTSD+DS | R | Middle temporal gyrus | 2,695 | 5.49 | <.001 | 66 | −40 | −6 | |
| R | Superior parietal lobule/supramarginal & angular gyri/TPJ | 2,695/subcluster | 4.89 | <.001 | 36 | −38 | 50 | ||
| PTSD+DS>HC | ns | ||||||||
| PTSD+DS>PTSD | ns | ||||||||
| PTSD>PTSD+DS | R | Middle temporal gyrus | 4,347 | 5.64 | <.001 | 66 | −40 | −4 | |
| R | Supramarginal and angular gyri/TPJ/parietal operculum/postcentral gyrus | 4,347/subcluster | 5.35 | <.001 | 66 | −28 | 26 | ||
| Seed region | Comparison | L/R | Brain region | k | Z | p | x | y | z |
|---|---|---|---|---|---|---|---|---|---|
| Right lobules IV–V | HC>PTSD | ns | |||||||
| PTSD>HC | R | Posterior insula | 527 | 4.22 | <.001 | 38 | −12 | 12 | |
| Planum polare/transverse temporal gyrus | 527/sublcuster | 4.02 | <.001 | 48 | −6 | −2 | |||
| HC>PTSD+DS | R | Middle temporal gyrus | 2,764 | 6.62 | <.001 | 68 | −40 | −4 | |
| R | Supramarginal and angular gyri/TPJ/parietal operculum/postcentral gyrus | 2,764/subcluster | 5.14 | <.001 | 60 | −56 | 26 | ||
| PTSD+DS>HC | ns | ||||||||
| PTSD+DS>PTSD | ns | ||||||||
| PTSD>PTSD+DS | R | Middle temporal gyrus | 3,467 | 5.95 | <.001 | 68 | −40 | −4 | |
| R | Supramarginal and angular gyri/TPJ/parietal operculum | 3,467/subcluster | 5.61 | <.001 | 66 | −28 | 26 | ||
| R | Superior temporal gyrus | 3,467/subcluster | 5.27 | <.001 | 64 | −44 | 20 |
| (c) Correlation with symptoms | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CAPS tot | Peak MNI coordinate | ||||||||
| Seed region | Correlation | L/R | Brain region | k | Z | p | x | y | z |
| Left lobules IV–V | Negative correlation | R | Postcentral gyrus | 581 | 3.89 | <.001 | 60 | −6 | 24 |
| R | Parietal operculum/supramarginal gyrus | 581/subcluster | 3.85 | <.001 | 56 | −28 | 32 | ||
| RSDI reliving | Peak MNI coordinate | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Seed region | Correlation | L/R | Brain region | k | Z | p | x | y | z |
| Left lobules IV–V | Positive correlation | L/R | Calcarine cortex/cuneus/lingual gyrus/fusiform gyrus | 4,808 | 4.34 | <.001 | 6 | −78 | 8 |
| Right lobules IV–V | Positive correlation | L/R | Calcarine cortex/cuneus/lingual gyrus | 2,826 | 4.19 | <.001 | 8 | −74 | −2 |
Note. Abbreviations: CAPS = Clinician Administered PTSD Scale; CNTR = control group; k = cluster extent; L = left hemisphere; PTSD = post‐traumatic stress disorder group; PTSD+DS = PTSD dissociative subtype group; R = right hemisphere; RSDI = Response Script‐Driven Imagery scale; SMA = supplementary motor area; TPJ = temporo‐parietal junction.
All results are reported at p < .05 whole‐brain corrected.