Table 2.
Regions of the cerebral WM tracts where NTG patients showed significant DTI abnormalities with respect to NC and POAG at TBSS analysis across the whole brain
| WM regions of the visual pathways (local maxima) | Side | MNI X, Y, Z (mm) | Cluster size (voxel no.) | P‐value |
|---|---|---|---|---|
| NTG vs NC | ||||
| FA: NTG < NC | ||||
| OT | L | −3,8,22 | 67 | <0.001 |
| AD: NTG>NC | ||||
| WM of LOC | R | 44,–61,–9 | 45 | 0.001 |
| R | 38,–80,–7 | 30 | <0.001 | |
| OR (IFOF/ILF) | R | 35,–75,–9 | 71 | 0.001 |
| L | −51,–6,–7 | 124 | 0.001 | |
| R | 24,–89,–6 | 50 | 0.001 | |
| R | 13,–80,–2 | 225 | <0.001 | |
| WM of LG | R | 26,–53,–1 | 91 | <0.001 |
| WM regions outside the visual pathways (local maxima) | ||||
| NTG vs. NC | ||||
| AD: NTG > NC | ||||
| WM of precuneus | R | 10,–59,27 | 54 | <0.001 |
| SLF (frontal) | R | 37,2,25 | 46 | 0.002 |
| RD: NTG > NC | ||||
| WM of frontopercular cortex/IFG | R | 45,13,11 | 32 | 0.001 |
| WM of SPL | R | −23,−51,56 | 31 | <0.001 |
| NTG vs. POAG | ||||
| AD: NTG < POAG | ||||
| WM of FOC | R | 21,28,–9 | 61 | <0.001 |
| WM of FP | R | 17,52,–5 | 51 | <0.001 |
| WM of SFG | L | −19,10,42 | 31 | <0.001 |
For each DTI measure, WM regions are ordered according to increasing Z values of local maxima. See text for details (including values of DTI measures) and abbreviations.