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. 2018 Feb 22;39(6):2442–2454. doi: 10.1002/hbm.24013

Table 2.

Group differences in the degree of local and distant connectivity

Cluster size (mm3) x (mm) y (mm) z (mm) TFCE p‐value
Local Connectivity
ADHD > ND
Right superior frontal gyrus 139,136 4 54 31 255.26 .001a
Left superior frontal gyrus/right superior frontal gyrus 0 53 24 249.98 .001a
Left superior frontal gyrus −8 50 40 249.08 .001a
Right occipital pole/right calcarine cortex 25,856 20 −92 5 216.56 .002
Right calcarine cortex 8 −92 6 209.21 .002
Left calcarine cortex −8 −97 −6 199.45 .002
Right middle frontal gyrus/right opercular part of the inferior frontal gyrus 9,152 36 9 26 201.60 .002
Right middle frontal gyrus/right precentral gyrus 56 18 34 173.58 .004
Right middle frontal gyrus 44 18 42 156.08 .005
Left medial orbital gyrus/left anterior cingulate gyrus 10,816 −12 30 −15 142.33 .007
Left medial frontal cortex −4 30 −19 136.70 .008
Left medial orbital gyrus −24 34 −15 135.82 .008
Right middle temporal gyrus 6,848 48 −37 2 138.80 .008
Right inferior temporal gyrus 64 −38 −22 96.54 .024
Right inferior temporal gyrus 56 −30 −23 92.95 .025
Right parietal operculum/right transverse temporal gyrus 8,384 36 −27 17 136.93 .008
Right planum polare 48 3 −5 130.99 .010
Right planum temporale/right transverse temporal gyrus 52 −9 0 90.79 .027
Left anterior insula 2,112 −32 24 2 113.34 .015
Left frontal operculum −40 16 2 100.80 .021
Right parahippocampal gyrus 448 16 −10 −24 100.29 .021
Right parahippocampal gyrus 20 −7 −33 72.27 .045
Left entorhinal area 3,776 −28 1 −37 98.54 .022
Left entorhinal area −32 −3 −29 94.87 .025
Left entorhinal area −20 −3 −29 82.41 .035
Left temporale pole 832 −52 9 −37 87.34 .030
Left temporale pole −44 16 −42 76.19 .041
Right lingual gyrus/right precuneus 1,856 4 −56 7 86.80 .030
Right lingual gyrus/right cerebellum 20 −41 −10 74.68 .043
Right lingual gyrus/right posterior cingulate gyrus 16 −49 −2 73.18 .045
Left caudate 1,216 −8 16 6 80.10 .036
Left caudate −16 12 10 78.44 .038
Left caudate −16 1 19 73.45 .045
Left thalamus proper 1,280 −8 −17 0 78.23 .038
Left thalamus proper/left caudate −16 −12 16 77.10 .040
Left thalamus proper −20 −21 1 74.36 .043
Left angular gryrus 768 −44 −66 44 76.87 .040
Left middle temporal gyrus 512 −64 2 −21 75.31 .042
Left middle temporal gyrus −56 1 −29 71.67 .046
ND > ADHD
Right posterior cingulate gyrus/right precuneus 512 20 −44 10 169.34 .005
Right middle occipital gyrus/right inferior occipital gyrus 4,160 44 −72 12 167.04 .005
Right middle occipital gyrus 44 −80 17 166.61 .005
Right middle occipital gyrus 36 −75 20 149.88 .007
Right precuneus/right superior parietal lobule 15,808 4 −48 75 163.59 .005
Right posterior cingulate gyrus 8 −38 38 160.77 .005
Right superior parietal lobe −8 −52 67 148.91 .007
Left inferior temporal gyrus 320 −52 −19 −31 94.26 .026
Distant Connectivity
ADHD > ND
None
ND > ADHD
Right posterior cingulate gyrus 896 20 −44 6 168.84 .006
Right fusiform gyrus/right inferior temporal gyrus 2,048 44 −26 −19 141.92 .012
Right hippocampus 32 −22 −16 118.06 .020
Right hippocampus 28 −14 −16 105.83 .026
Right superior frontal gyrus 192 24 20 62 119.50 .019
Right hippocampus 384 32 −33 −3 98.20 .031
Right hippocampus/right lingual gyrus 28 −41 −2 95.78 .033
Right cerebellum 448 16 −67 −36 92.27 .036
Right cerebellum 24 −68 −40 85.30 .043
Left cerebellum 384 −28 −64 −40 89.99 .038

Coordinates are based on MNI152 stereotactic space. Results reported in the table correspond to those clusters above 192 mm3 (three contiguous voxels).

Abbreviations: ADHD = children with attention‐deficit/hyperactivity disorder; ND = neurotypically developing children. TFCE = threshold‐free cluster enhancement; FWE = family‐wise error.

a

Significant at p < .05 TFCE–FWE level.