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. 2018 Feb 22;39(6):2442–2454. doi: 10.1002/hbm.24013

Table 3.

Group by age interaction

Cluster Size (mm³) x (mm) y (mm) z (mm) TFCE p‐value
Local Connectivity
Increases with age in ADHD and Decreases in ND
Left postcentral gyrus 35,584 −44 −22 41 217.03 .002a
Left precentral gyrus −36 −17 49 207.50 .002
Left supramarginal gyrus −56 −26 41 202.97 .002
Cerebellar vermal lobules 52,480 0 −46 −14 194.55 .003
Left thalamus proper −20 −29 1 187.25 .003
Left thalamus proper −12 −28 9 182.88 .003
Right superior temporal gyrus 6,656 56 −13 0 129.26 .010
Right superior temporal gyrus 64 −13 0 108.93 .017
Right transverse temporal gyrus 48 −20 4 91.29 .027
Right superior parietal lobule 17,024 28 −65 56 126.85 .011
Right superior parietal lobule 24 −60 67 117.94 .014
Right precentral gyrus 20 −19 77 116.79 .014
Left frontal pole 16,000 −28 64 3 111.35 .016
Left anterior orbital gyrus/left lateral orbital gyrus −32 50 −20 108.26 .017
Left anterior orbital gyrus/left frontal pole −24 62 −17 101.13 .021
Right middle cingulate gyrus 5,632 4 −2 35 106.83 .018
Right supplementary motor cortex 8 23 46 104.81 .019
Right supplementary motor cortex 12 7 51 98.34 .023
Left cerebellum 3,968 −16 −87 −27 95.28 .025
Left cerebellum −8 −82 −23 91.55 .027
Left cerebellum −24 −91 −27 86.70 .031
Left anterior cingulate gyrus 3,840 −4 39 −4 94.47 .025
Left gyrus rectus 0 42 −24 94.34 .025
Left superior frontal gyrus/left medial frontal cortex −12 51 −4 86.24 .032
Right anterior insula 3,392 44 11 −10 93.19 .026
Right temporal pole/right anterior insula 44 18 −14 90.29 .028
Right anterior insula/right posterior orbital gyrus 36 23 −11 89.97 .029
Right supplementary motor cortex 192 12 −10 44 91.03 .028
Left superior frontal gyrus 448 −20 57 19 82.06 .035
Right supplementary motor cortex 1,088 4 16 62 76.22 .042
Supplementary motor cortex 0 8 71 73.83 .045
Left parahippocampal gyrus 384 −28 −15 −32 76.12 .042
Left cerebellum 192 −36 −67 −32 75.45 .043
Left cerebellum 448 −32 −44 −42 74.64 .045
Left cerebellum −32 −40 −50 74.07 .045
Right superior temporal gyrus 320 64 7 −2 74.60 .045
Right lateral orbital gyrus 256 44 47 −12 71.89 .047
Right precuneus 192 4 −54 43 70.34 .050
Increases with age in ND and Decreases in ADHD
None
Distant Connectivity
Increases with age in ADHD and Decreases in ND
None
Increases with age in ND and Decreases in ADHD
Right Supramarginal Gyrus 448 60 −46 38 103.7 .030

Effect of the interaction of age and group differences in the degree of local and distant connectivity. Coordinates are based on MNI152 stereotactic space. Results reported in the table correspond to those clusters above 192 mm3 (three contiguous voxels).

Abbreviations: ADHD = children with attention‐deficit/hyperactivity disorder; ND = neurotypically developing children; TFCE = threshold‐free cluster enhancement.

a

FWE‐corrected p‐value = .051.