Table 2.

Age‐related differences in (a) whole‐lobe and (b) hemispheric DTI measures across the brain for participants in the cross‐sectional cohort

a
DTI measure	Intercept	Slope	SE	R 2	P	q
FA
Frontal	0.325	0.0031	0.0012	0.06	0.018	0.023
Parietal	0.310	0.0025	0.0011	0.05	0.074	0.049
Temporal	0.274	0.0027	0.0012	0.08	0.012	0.043
Occipital	0.226	0.0010	0.0013	0.02	0.607	0.539
MD	mm2/s	mm2/s/year
Frontal	0.0008	−6.27 × 10−6	8.74 × 10−7	0.40	5.67 × 10−10	<0.0001
Parietal	0.0008	−3.75 × 10−6	8.78 × 10−7	0.21	6.07 × 10−5	<0.001
Temporal	0.0009	−3.32 × 10−6	9.91 × 10−7	0.11	0.0013	0.003
Occipital	0.0008	−6.13 × 10−7	1.14 × 10−6	‐	0.593	0.633
AD	mm2/s	mm2/s/year
Frontal	0.0011	−6.20 × 10−6	1.37 × 10−6	0.24	2.30 × 10−5	<0.001
Parietal	0.0011	−3.19 × 10−6	1.48 × 10−6	0.12	0.034	0.049
Temporal	0.0011	−1.99 × 10−6	1.79 × 10−6	0.01	0.090	0.120
Occipital	0.0010	−8.34 × 10−6	1.32 × 10−6	0.04	0.530	0.606
RD	mm2/s	mm2/s/year
Frontal	0.0007	−6.30 × 10−6	1.10 × 10−6	0.28	2.12 × 10−7	<0.0001
Parietal	0.0007	−4.00 × 10−6	1.07 × 10−6	0.14	0.0004	0.0011
Temporal	0.0007	−3.98 × 10−6	1.08 × 10−6	0.15	0.0005	0.0012
Occipital	0.0007	−4.98 × 10−7	1.44 × 10−6	‐	0.731	0.731

b
DTI measure	Left hemisphere				Right hemisphere
	Intercept	Slope	R 2	q	Intercept	Slope	R 2	q
FA
Frontal	0.355	0.004	0.11	0.003	0.391	0.002	0.02	0.14
Parietal	0.357	0.002	0.01	0.22	0.323	0.003	0.12	0.02
Temporal	0.332	0.003	0.10	0.02	0.357	0.002	0.03	0.15
Occipital	0.337	0.001	‐	0.57	0.300	0.001	‐	0.55
MD	mm2/s	mm2/s/yr (× 10−6)			mm2/s	mm2/s/yr (× 10−6)
Frontal	0.00088	−7.47	0.37	<0.0001	0.00082	−5.06	0.29	<0.0001
Parietal	0.00083	−2.67	0.10	0.02	0.00088	−4.81	0.22	0.0001
Temporal	0.0009	−2.22	0.02	0.07	0.00089	−4.41	0.19	0.0003
Occipital	0.00079	−1.28	‐	0.37	0.00084	0.06	‐	0.98
AD	mm2/s	mm2/s/yr (× 10−6)			mm2/s	mm2/s/yr (× 10−6)
Frontal	0.0012	−7.02	0.17	0.0003	0.0012	−5.35	0.21	0.0006
Parietal	0.0012	−2.57	0.12	0.14	0.0012	−3.79	0.07	0.05
Temporal	0.0012	−0.60	‐	0.82	0.0012	−4.60	0.05	0.03
Occipital	0.0011	−1.70	0.01	0.31	0.0011	−7.06	‐	0.98
RD	mm2/s	mm2/s/yr (× 10−6)			mm2/s	mm2/s/yr (× 10−6)
Frontal	0.00070	−7.71	0.02	<0.0001	0.00064	−4.67	0.17	0.0003
Parietal	0.00066	−2.71	0.02	0.05	0.00072	−5.28	0.23	0.0001
Temporal	0.00074	−3.64	0.11	0.005	0.00071	−4.3	0.17	0.001
Occipital	0.00064	−1.10	‐	0.57	0.00070	0.48	‐	0.98

SE—Standard error of slope.

q—FDR‐adjusted p‐values. Values that survived FDR correction are bolded.