Table 3.
Age‐related changes in (a) whole‐lobe and (b) hemispheric DTI measures across the brain for participants in the primarily longitudinal cohort
a | ||||||
---|---|---|---|---|---|---|
DTI measure | Intercept | Slope | SE | R 2 | P | q |
FA | ||||||
Frontal | 0.324 | 0.0031 | 0.0009 | 0.25 | 0.002 | 0.034 |
Parietal | 0.356 | 0.0031 | 0.0013 | 0.15 | 0.027 | 0.110 |
Temporal | 0.282 | 0.0034 | 0.0014 | 0.21 | 0.017 | 0.110 |
Occipital | 0.235 | 0.0034 | 0.0015 | 0.17 | 0.024 | 0.110 |
MD | mm2/s | mm2/s/year | ||||
Frontal | 0.0008 | −6.06 × 10−6 | 2.27 × 10−6 | 0.23 | 0.087 | 0.200 |
Parietal | 0.0007 | −4.17 × 10−6 | 2.59 × 10−6 | 0.11 | 0.224 | 0.282 |
temporal | 0.0008 | −5.35 × 10−6 | 2.38 × 10−6 | 0.18 | 0.122 | 0.243 |
Occipital | 0.0008 | −4.01 × 10−6 | 2.33 × 10−6 | 0.13 | 0.208 | 0.282 |
AD | mm2/s | mm2/s/year | ||||
Frontal | 0.0010 | −4.60 × 10−6 | 3.05 × 10−6 | 0.14 | 0.229 | 0.282 |
Parietal | 0.0011 | −3.62 × 10−6 | 2.95 × 10−6 | 0.13 | 0.308 | 0.352 |
Temporal | 0.0011 | −3.15 × 10−6 | 3.39 × 10−6 | 0.04 | 0.414 | 0.442 |
Occipital | 0.0010 | −1.99 × 10−6 | 2.98 × 10−6 | 0.08 | 0.553 | 0.553 |
RD | mm2/s | mm2/s/year | ||||
Frontal | 0.0006 | −6.44 × 10−6 | 2.04 × 10−6 | 0.22 | 0.065 | 0.200 |
Parietal | 0.0006 | −4.57 × 10−6 | 2.61 × 10−6 | 0.11 | 0.201 | 0.282 |
Temporal | 0.0007 | −6.21 × 10−6 | 2.12 × 10−6 | 0.19 | 0.088 | 0.200 |
Occipital | 0.0007 | −4.38 × 10−6 | 2.27 × 10−6 | 0.09 | 0.186 | 0.282 |
b | ||||||||
---|---|---|---|---|---|---|---|---|
DTI measure | Left hemisphere | Right hemisphere | ||||||
Intercept | Slope | R 2 | q | Intercept | Slope | R 2 | q | |
FA | ||||||||
Frontal | 0.331 | 0.0035 | 0.27 | 0.03 | 0.320 | 0.0027 | 0.18 | 0.13 |
Parietal | 0.347 | 0.0046 | 0.25 | 0.03 | 0.364 | 0.0017 | 0.05 | 0.71 |
Temporal | 0.281 | 0.0048 | 0.28 | 0.03 | 0.278 | 0.0023 | 0.14 | 0.26 |
Occipital | 0.281 | 0.003 | 0.10 | 0.24 | 0.178 | 0.0038 | 0.27 | 0.21 |
MD | mm2/s |
mm2/s/yr (× 10−6) |
mm2/s |
mm2/s/yr (× 10−6) |
||||
Frontal | 0.00073 | −6.53 | 0.27 | 0.25 | 0.0008 | −5.57 | 0.19 | 0.25 |
Parietal | 0.00074 | −5.44 | 0.14 | 0.26 | 0.00076 | −3.09 | 0.08 | 0.42 |
Temporal | 0.00084 | −5.37 | 0.16 | 0.25 | 0.00084 | −5.29 | 0.20 | 0.25 |
Occipital | 0.00075 | −5.53 | 0.14 | 0.25 | 0.00087 | −1.74 | 0.05 | 0.60 |
AD | mm2/s |
mm2/s/yr (× 10−6) |
mm2/s |
mm2/s/yr (× 10−6) |
||||
Frontal | 0.001 | −4.96 | 0.18 | 0.31 | 0.001 | −4.20 | 0.10 | 0.39 |
Parietal | 0.001 | −3.43 | 0.10 | 0.42 | 0.001 | −3.81 | 0.16 | 0.39 |
Temporal | 0.001 | −1.90 | 0.02 | 0.65 | 0.001 | −4.32 | 0.06 | 0.39 |
Occipital | 0.00095 | −4.98 | 0.14 | 0.30 | 0.00097 | 0.92 | 0.06 | 0.79 |
RD | mm2/s |
mm2/s/yr (× 10−6) |
mm2/s |
mm2/s/yr (× 10−6) |
||||
Frontal | 0.00058 | −7.04 | 0.27 | 0.24 | 0.00067 | −6.02 | 0.19 | 0.24 |
Parietal | 0.00059 | −6.55 | 0.19 | 0.25 | 0.00060 | −2.84 | 0.06 | 0.45 |
Temporal | 0.00071 | −7.03 | 0.21 | 0.24 | 0.00071 | −5.07 | 0.15 | 0.26 |
Occipital | 0.00062 | −5.44 | 0.13 | 0.25 | 0.00079 | −2.16 | 0.13 | 0.55 |
SE—Standard error of slope.
q—FDR‐adjusted p‐values. Values that survived FDR correction are bolded.