Table 4.

DTI metrics for frontal–thalamic pathways

	Control		bvFTD
Cortical seed	M	SD	M	SD	p value	Effect size
DLPFC
FA	0.41	0.03	0.36	0.03	<.001	1.53
AD	1.20	0.41	1.34	0.41	<.001	0.33
RD	0.64	0.24	0.79	0.24	<.001	0.61
MD	0.83	0.07	0.97	0.06	<.001	2.19
MPFC
FA	0.36	0.15	0.33	0.15	.002	0.20
AD	1.41	0.73	1.45	0.73	.369	0.06
RD	0.85	0.73	0.92	0.73	.119	0.09
MD	1.04	0.78	1.10	0.78	.180	0.07
OFC
FA	0.39	0.03	0.33	0.03	<.001	1.60
AD	1.31	0.58	1.46	0.58	<.005	0.25
RD	0.76	0.45	0.93	0.45	<.001	0.38
MD	0.94	0.33	1.10	0.34	<.001	0.48

Note. Abbreviations: AD = apparent diffusivity; bvFTD = behavioral variant frontotemporal dementia; DLPFC = dorsolateral prefrontal cortex; FA = fractional anisotropy; MD = mean diffusivity; MPFC = medial prefrontal cortex; OFC = orbitofrontal cortex; RD = radial diffusivity.

Estimated marginal mean DTI metrics (AD, RD, and MD all ×10⁻³) and significance tests from separate linear mixed models, controlling for hemisphere, age, gender, and education.