Table 5.
Volumes (voxels) of subcortical regions with unique connections to frontal regions
| Control | bvFTD | |||||
|---|---|---|---|---|---|---|
| Structure | M | SD | M | SD | p value | Effect size |
| Striatum | ||||||
| DLPFC | 482 | 167 | 322 | 162 | .002 | 0.961 |
| MPFC | 141 | 64 | 191 | 83 | .032 | 0.785 |
| OFC | 195 | 157 | 117 | 88 | .036 | 0.498 |
| Thalamus | ||||||
| DLPFC | 391 | 191 | 255 | 181 | .020 | 0.712 |
| MPFC | 41 | 34 | 89 | 73 | .004 | 1.400 |
| OFC | 43 | 64 | 45 | 69 | .927 | 0.031 |
Note. Abbreviations: bvFTD = behavioral variant frontotemporal dementia; DLPFC = dorsolateral prefrontal cortex; MPFC = medial prefrontal cortex; OFC = orbitofrontal cortex.
Estimated marginal mean voxels and significance test from separate linear mixed models, controlling for hemisphere, age, gender, education, and intracranial volume.
Note that the relatively large SD of the MPFC and OFC tracts reflects the positively skewed distribution, for which a Gamma‐log link function was used.