Table 4.

Coefficients of correlation between WMH loads in different lobes and cognitive measures for ADNI1 subjects, controlling for age

	Test	LFL	RFL	LPL	RPL	LTL	RTL	LOL	ROL	WB
T1+T2+PD	MMSE	−0.165*	−0.171*	−0.139*	−0.145*	−0.081*	−0.090*	−0.125*	−0.134*	−0.174*
	ADAS11	0.203*	0.199*	0.183*	0.192*	0.108*	0.131*	0.129*	0.172*	0.217*
	ADAS13	0.219*	0.217*	0.201*	0.199*	0.127*	0.151*	0.141*	0.190*	0.236*
	FAQ	0.209*	0.215*	0.171*	0.192*	0.109*	0.128*	0.139*	0.208*	0.216*
	RAVLTI	−0.174*	−0.179*	−0.161*	−0.163*	−0.119*	−0.168*	−0.130*	−0.157*	−0.197*
	RAVLTF	0.074	0.051	0.062	−0.028	−0.005	−0.005	−0.023	−0.020	−0.061
	RAVLTL	−0.084*	−0.100*	−0.079	−0.079	−0.070	−0.085*	−0.084*	−0.095*	−0.103*
	Executive	−0.111*	−0.110*	−0.121*	−0.107*	−0.112*	−0.113*	−0.182*	−0.139*	−0.130*
	NPI	0.210*	0.199*	0.279*	0.273*	0.270*	0.239*	0.242*	0.221*	0.277*
Only T1	MMSE	−0.203*	−0.211*	−0.127*	−0.147*	−0.031	−0.057	−0.144*	−0.162*	−0.187*
	ADAS11	0.231*	0.230*	0.149*	0.180*	0.054	0.083*	0.132*	0.146*	0.217*
	ADAS13	0.251*	0.251*	0.168*	0.186*	0.069	0.092*	0.148*	0.156*	0.236*
	FAQ	0.226*	0.238*	0.150*	0.182*	0.065	0.089*	0.160*	0.224*	0.218*
	RAVLTI	−0.220*	−0.217*	−0.166*	−0.179*	−0.100*	−0.130*	−0.133*	−0.141*	−0.217*
	RAVLTF	0.074	0.067	0.054	0.043	0.053	0.033	0.036	0.044	0.073
	RAVLTL	−0.109*	−0.113*	−0.059	−0.070	−0.020	−0.037	−0.070	−0.084*	−0.097*
	Executive	−0.128*	−0.135*	−0.117*	−0.113*	−0.018	−0.077	−0.124*	−0.092*	−0.130*
	NPI	0.228*	0.237*	0.308*	0.300*	0.211*	0.200*	0.200*	0.228*	0.290*

Note. WMH = white matter hyperintensity; LFL/RFL = left/right frontal lobe; LPL/RPL = left/right parietal lobe; LTL/RTL = left/right temporal lobe; LOL/ROL = left/right occipital lobe; WB = whole brain; MMSE = Mini‐Mental State Examination; ADAS = Alzheimer's Disease Assessment Scale; FAQ = Functional Assessment Questionnaire; RAVLT = Rey Auditory Verbal Learning Task (I = Immediate, F = Forgetting, L = Learning); Executive = executive function (Gibbons et al., 2012); NPI = Total Neuropsychiatric Inventory Score.