Table 3.
Reduced FA in trauma exposed controls versus healthy controls (whole‐brain TBSS analysis with FWE correction)
| Anatomic region | Hemisphere | MNI coordinates | Cluster size (voxels) | PTSD, mean ± SD | HC, mean ± SD | FWE corrected, p value (max) |
|---|---|---|---|---|---|---|
| Anterior thalamic radiation | Left | −26, 26, 16 | 219 | 0.4041 ± 0.0316 | 0.4411 ± 0.0231 | .017 |
| Anterior thalamic radiation | Right | 28, 30, 18 | 102 | 0.3659 ± 0.0277 | 0.3947 ± 0.0289 | .032 |
| Cingulum cingulate gyrus | Left | −18, −36, 33 | 58 | 0.5133 ± 0.0371 | 0.5465 ± 0.0292 | .035 |
| Cingulum cingulate gyrus | Right | 20, 30, 31 | 10 | 0.4711 ± 0.0562 | 0.4988 ± 0.0651 | .036 |
| Corpus Callosum Body | Midline | −12, 19, 22 | 1499 | 0.7146 ± 0.0282 | 0.7443 ± 0.0208 | .030 |
| Corpus Callosum Genu | Midline | −6, 28, −1 | 1160 | 0.7479 ± 0.0300 | 0.7811 ± 0.0177 | .008 |
| Corpus Callosum Splenium | Midline | −18, −41, 28 | 68 | 0.6691 ± 0.0264 | 0.6975 ± 0.0313 | .034 |
| Superior longitudinal fasciculus | Left | −34, 13, 12 | 221 | 0.4473 ± 0.0353 | 0.4877 ± 0.0259 | .015 |
| Superior longitudinal fasciculus | Right | 34, 19, 21 | 22 | 0.4665 ± 0.0433 | 0.5129 ± 0.0224 | .032 |
| Uncinate fasciculus | Left | −19, 22, −10 | 647 | 0.4902 ± 0.0228 | 0.5245 ± 0.0160 | .016 |
| Uncinate fasciculus | Right | 15, 34, −6 | 402 | 0.5000 ± 0.0277 | 0.5305 ± 0.0229 | .014 |