Figure 1.

The Network Modification tool: A WM abnormality mask is registered to the Montreal Neurological Institute standard space. Then, an in‐software database of HC tractograms are referenced in order to determine the proportion of streamlines in a WM tract bundle, connected to a GM region, which are disrupted by WM abnormalities. WM tract disruption was evaluated for all GM structures included in the 86 region FreeSurfer brain parcellation. Tract disruption was also calculated in a pairwise manner, indicating the proportion of disrupted tracts between each pair of structurally connected GM regions [Color figure can be viewed at http://wileyonlinelibrary.com]