Table 3.

Univariate correlations and hierarchical regression models between memory composite scores at baseline or after 1 year follow‐up (dependent variables) and demographical, clinical, and MRI features

		Explanatory variables	Univariate analysis (r)	Multivariate analysis (ß)	Adjusted multivariate model (R 2)
Baseline
Episodic verbal memory	Block 1	Age	−0.04	ns	ns
		T2LL	−0.20	ns
		NBV	0.12	ns
		Education level	0.32*	0.38*
	Block 2 a	‐	‐	‐	‐
Episodic spatial memory	Block 1	Age	−0.18	ns	ns
		T2LL	−0.18	ns
		NBV	0.17	ns
		Education level	0.32*	ns
	Block 2 a	‐	‐	‐	‐
1 year
Episodic verbal memory	Block 1	Age	−0.15	ns	ns
		T2LL	−0.14	ns
		NBV	0.17	ns
		Education level	0.24	ns
	Block 2	Age	−0.15	ns	0.26*
		T2LL	−0.14	ns
		NBV	0.17	ns
		Education level	0.24	0.51*
		CA1‐SP	0.30*	0.87*
		CA1‐SRLM	0.24	ns
Episodic spatial memory	Block 1	Age	−0.35*	ns	ns
		T2LL	−0.17	ns
		NBV	−0.03	ns
		Education level	0.14	ns
	Block 2 a	‐	‐	‐	‐

Note. Abbreviations: CA1‐SP = CA1‐stratum pyramidale; CA1‐SRLM = CA1‐stratum radiatum‐lacunosum‐moleculare; T2LL = T2 lesion load; NBV = normalized brain volume; ns = nonsignificant.

Age, T2LL, NBV, and educational level were entered into an initial model (Block 1) as nuisance variables. Covariables related to hippocampal subfields were added in a second model (Block 2) according to univariate correlations (p value < .2) to predict memory scores.

^aBlock 2 was equivalent to Block 1 because no correlation (p < .2) was found between the volume of any hippocampal subfields and the memory score

*p < .05.