Table 2.
Brain stimulation‐induced neuroplastic changes associated with therapeutic response in phantom sounds
| Brain region | Cluster size | MNI coordinates | |||||
|---|---|---|---|---|---|---|---|
| Macroanatomic | Cytoarchitectonic | in voxels | x | y | z | P value | |
| L | DLPFC/VLPFC | 3610 | −34 | 27 | −5 | 0.007 | |
| L | Operculo‐insular cortex/Claustrum | Areae OP2/3, TE 1.1 | 1149 | −30 | −40 | 6 | 0.029 |
| R | Inferior temporal cortex | FG1 | 498 | 46 | −60 | −15 | 0.036 |
Significant group (non‐/responders) × time (pre‐/post‐stimulation) interactions in whole‐brain voxel‐based morphometric (VBM) analyses (P < 0.05, FWE corrected). Post‐hoc tests revealed that the interaction was driven by a longitudinal gray matter (GM) decrease in all three regions specifically in responders. Coordinates represent peaks within a cluster. For detailed information on cytoarchitectonics, see publications by Caspers (FG1), Eickhoff (OP2/3), Lorenz (FG1), Morosan (TE 1.1), and colleagues [Caspers et al., 2013; Eickhoff et al., 2006a, 2006c; Lorenz et al., 2017; Morosan et al., 2001].
DLPFC, dorsolateral prefrontal cortex; FWE, familywise error; L, left; MNI, Montreal Neurological Institute; R, right; TFCE, threshold‐free cluster enhancement; VLPFC, ventrolateral prefrontal cortex.