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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Psychiatr Res. 2019 Oct 26;120:154–162. doi: 10.1016/j.jpsychires.2019.10.019

Table 2:

Overview of partial correlation estimates between the depression score and the DNAm at single CpG sites, using PC1+2 generated from genotype data (for Grady and PReDICT only), sex, age, smoking behavior and CTQ total score as covariates. Results shown for Tuebingen (N=151), PReDICT (N=299) and Grady (N=310) datasets. Only sites that were nominally significant in at least one of the three datasets are listed. Total number of analyzed sites was 50 for Tuebingen and 12 for Grady and PReDICT cohort. Unstandardized betas for depression score are shown in brackets and in italic letters. Both estimates are rounded to two decimal places, abs<x denotes that the absolute value is smaller than x. Statistical significance of depression score as predictor of DNAm was assessed using multiple regression analysis. Nominally significant associations are marked in bold and designated with * =p-value<=0.05, **=p-value<=0.01, ***=p-value<=0.001. Sites are described by genomic position (hg19). Results that withstand FDR-correction are underlined. Mean DNAm was calculated from all analyzed sites (50, 12, 12).

Tuebingen PReDICT Grady
Ch3:108.836.796 0.17 * (0.03) NA NA
Chr3:108.836.878 0.06 (0.01) −0.1 (−0.01) 0.17 * (0.01)
Chr3:108.837.069 0.01 (abs<0.01) −0.05 (−0.01) 0.1 * (0.01)
Chr3:108.837.086 abs<0.01 (abs< 0.01) abs<0.01 (−0.01) 0.16 ** (0.02)
Chr3:108.837.088 0.03 (abs<0.01) −0.07 (−0.02) 0.19 *** (0.02)
Chr3:108.837.620 NA abs<0.01(abs<0.01) 0.13 * (0.01)
Mean of all analyzed sites 0.15 (0.01) −0.06 * (−0.01) 0.15 * (0.01)