Table 3.
Bayesian model averaging statistical analyses
| Node pair in Bayesian model averaging | Intrinsic inhibitory connection | Levene's homogeneity test | ANOVA or Welch's ANOVA | Post hoc comparison | Tukey's HSD or games Howell |
|---|---|---|---|---|---|
| Left CMA & PAG | Left CMA | F(2, 153) = 9.729, P < 0.001* | F(2, 83.056) = 4.902, P < 0.010 | PTSD & PTSD+DS | ns |
| PTSD & Control | ns | ||||
| PTSD+DS > Control | P = 0.034 | ||||
| Left BLA & vmPFC | Left BLA | F(2, 153) = 3.440, P < 0.001* | F(2, 90.601) = 3.675, P < 0.030 | PTSD & PTSD+DS | ns |
| PTSD & Control | ns | ||||
| PTSD+DS < Control | P = 0.031 | ||||
| Left CMA & vmPFC | vmPFC | F(2, 153) = 9.129, P < 0.001* | F(2, 85.146) = 3.835, P < 0.025 | PTSD & PTSD+DS | ns |
| PTSD > Control | ns | ||||
| PTSD+DS > Control | P = 0.020 | ||||
| Right BLA & vmPFC | vmPFC | F(2, 153) = 5.874, P < 0.005* | F(2, 87.498) = 3.880, P < 0.025 | PTSD & PTSD+DS | ns |
| PTSD & Control | ns | ||||
| PTSD+DS > Control | P = 0.023 | ||||
| Right CMA & vmPFC | Right CMA | F(2, 153) = 0.315, ns | F(2, 153) = 7.372, P < 0.001 | PTSD > PTSD+DS | P = 0.018 |
| PTSD & Control | ns | ||||
| PTSD+DS < Control | P = 0.001 | ||||
| vmPFC | F(2, 153) = 13.168, P < 0.001* | F(2, 81.156) = 12.635, P < 0.001 | PTSD < PTSD+DS | ns | |
| PTSD > Control | P = 0.005 | ||||
| PTSD+DS > Control | P < 0.001 | ||||
| PAG & vmPFC | PAG | F(2, 153) = 0.473, ns | F(2, 153) = 7.103, P < 0.001 | PTSD > PTSD+DS | P = 0.019 |
| PTSD & Control | ns | ||||
| PTSD+DS < Control | P < 0.001 | ||||
| vmPFC | F(2, 153) = 5.587, P < 0.005* | F(2, 86.350) = 6.004, P < 0.004 | PTSD & PTSD+DS | ns | |
| PTSD & Control | ns | ||||
| PTSD+DS > Control | P = 0.003 |
Univariate analyses following significant multivariate effects. If a significant Levene's test was detected (*), Welch's ANOVA and Games Howell post hoc tests were conducted to account for unequal variances. The “post hoc comparison” column denotes the direction of group differences via “< or >” if a significant post hoc analysis was detected. Abbreviations: PTSD = posttraumatic stress disorder, PTSD + DS = dissociative subtype posttraumatic stress disorder patients, CMA = centromedial amygdala, BLA = basolateral amygdala, PAG = periaqueductal gray, vmPFC = ventromedial prefrontal cortex, HSD = Tukey's honestly significant difference.