Table I.
Demographic and clinical characteristics of patients with major depressive disorder and healthy controls
| MDD (n = 113) | HC (n = 86) | P value | |
|---|---|---|---|
| Age | 42.78 ± 1.07 | 39.23 ± 1.46 | 0.051 |
| Gender (female/male) | 90/23 | 59/27 | 0.099 |
| Education level | |||
| Elementary and middle school | 25 | 11 | 0.128 |
| High school or college/university | 80 | 64 | |
| Above graduate school | 8 | 11 | |
| HDRS‐17 score | 15.05 ± 0.74 | 2.23 ± 0.23 | <0.001 |
| Duration of illness (months) | 45.81 ± 4.60 | ||
| TPH2 gene rs4570625 | |||
| TT | 26 | 30 | 0.174 |
| TG | 60 | 40 | |
| GG | 27 | 16 | |
| HWE | 0.510 | 0.680 | |
| TT + TG | 86 | 70 | 0.391 |
| GG | 27 | 16 | |
| T (allele frequency) | 112 | 100 | 0.105 |
| G (allele frequency) | 114 | 72 | |
| Drug‐naïve/Antidepressant | 52/61 | ||
| TT + TG | 38/48 | 0.514 | |
| GG | 14/13 | ||
| Antidepressant type | |||
| SSRI | 31 | ||
| SNRI | 9 | ||
| NDRI | 6 | ||
| NaSSA | 4 | ||
| Combination | 11 |
Data are means ± standard error for age, HDRS‐17 scores, and duration of illness.
The P values for distributions of gender, education level, TPH2 genotype, allele frequency, and drug‐naïve patients according to the genotype were obtained by chi‐square test.
The P values for comparisons of age and HDRS‐17 scores were obtained using independent t‐tests.
Allele frequencies (T/G): MDD patients 0.50/0.50, HC subjects 0.58/0.42.
MDD, major depressive disorder; HC, healthy controls; HDRS‐17, Hamilton Depression Rating Scale; HWE, Hardy‐Weinberg equilibrium; SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin and norepinephrine reuptake inhibitor; NDRI, norepinephrine‐dopamine reuptake inhibitor; NaSSA, noradrenergic and specific serotonergic antidepressant; Combination, combinations of two or more types of antidepressants.