Table 2.
Dual‐regression results from the between group comparisons; corrected for multiple comparisons with threshold‐free cluster enhancement (TFCE, P‐value < 0.05)
| Dual‐regression, cluster index | Number of Voxels | Min P‐value | MNI coordinate | Brain regions—Harvard–Oxford atlas |
|---|---|---|---|---|
| HC > PD‐NC | ||||
| RFPN‐01 | 10 | 0.024 | 42,−38,36 | R supramarginal gyrus |
| DAN‐02 | 158 | 0.009 | 38,−2,40 | R precentral gyrus, R middle frontal gyrus |
| DAN‐03 | 144 | 0.005 | 58,−6,44 | R precentral gyrus, R postcentral gyrus |
| DAN‐04 | 43 | 0.017 | −6,−14,60 | L supplementary motor area, L precentral gyrus. |
| DAN‐05 | 34 | 0.022 | −10,−62,64 | L lateral occipital cortex, L precuneus cortex |
| DAN‐06 | 20 | 0.022 | 50,50,4 | R frontal pole |
| DAN‐07 | 18 | 0.036 | 18,−6,64 | R superior frontal gyrus |
| DAN‐08 | 17 | 0.038 | 62,−14,8 | R planum temporale |
| DAN‐09 | 8 | 0.04 | −14,−46,76 | L postcentral gyrus |
| DAN‐10 | 5 | 0.038 | −10,−78,52 | L lateral occipital cortex, superior division |
| DAN‐11 | 3 | 0.03 | −66,−50,36 | L supramarginal gyrus, posterior division |
| DAN‐12 | 2 | 0.048 | −18,−78,52 | L lateral occipital cortex, superior division |
| DAN‐13 | 1 | 0.048 | 42,−82,24 | R lateral occipital cortex, superior division |
| MN2‐14 | 601 | 0.001 | −42,−78,40 | L lateral occipital cortex, R cuneal cortex, R occipital cortex, L precentral gyrus, R lateral occipital cortex |
| MN2‐15 | 73 | 0.026 | 26,−54,72 | R superior parietal lobule |
| MN2‐16 | 32 | 0.013 | 34,26,16 | R inferior frontal gyrus, pars opercularis |
| MN2‐17 | 5 | 0.042 | −10,−18,36 | L cingulate gyrus, posterior division |
| MN2‐18 | 3 | 0.044 | 62,6,−4 | R superior temporal gyrus, anterior division |
| MN2‐19 | 2 | 0.05 | 2,−62,36 | R precuneus cortex |
| FPN‐20 | 192 | 0.013 | 38,−26,64 | R postcentral gyrus, R middle frontal gyrus, R superior parietal lobule, R precentral gyrus. |
| FPN‐21 | 25 | 0.014 | 38,22,32 | R middle frontal gyrus |
| FPN‐22 | 17 | 0.039 | 46,−46,60 | R superior parietal lobule |
| HC < PD‐NC | ||||
| LFPN‐23 | 9 | 0.031 | −10,26,−4 | L subcallosal cortex. |
| HC > PD‐MCI | ||||
| TEMP‐24 | 30 | 0.02 | 62,6,40 | R precentral gyrus. |
| VN2‐25 | 22 | 0.019 | −42,−18,56 | L precentral gyrus. |
| DAN‐26 | 8 | 0.031 | 50,50,0 | R frontal pole. |
| PD‐NC > PD‐MCI | ||||
| RFPN‐27 | 1 | 0.043 | −2,−62,36 | L precuneus cortex. |
| VAN‐28 | 22 | 0.025 | 18,−10,40 | R precentral gyrus, R cingulate gyrus. |
| VAN‐29 | 21 | 0.018 | 58,−2,40 | R precentral gyrus. |
| VAN‐30 | 9 | 0.046 | 2,−6,32 | R cingulate gyrus, anterior division. |
| VAN‐31 | 2 | 0.05 | −2,22,64 | L superior frontal gyrus. |
| dmPFN‐32 | 738 | 0.007 | −26,6,68 | L middle frontal gyrus, L precentral gyrus, L postcentral gyrus, R supplementary motor cortex. |
| dmPFN–33 | 56 | 0.017 | 14,62,−8 | R frontal pole, L frontal pole. |
| dmPFN–34 | 25 | 0.033 | 18,−54,76 | R superior parietal lobule. |
| dmPFN–35 | 9 | 0.031 | −26,50,36 | L frontal pole. |
| dmPFN–36 | 6 | 0.043 | 34,54,−16 | R frontal pole. |
| dmPFN–37 | 4 | 0.046 | 42,10,60 | R middle frontal gyrus. |
| dmPFN–38 | 4 | 0.04 | −6,54,44 | L frontal pole. |
| dmPFN–39 | 2 | 0.04 | 6,66,24 | R frontal pole. |
| dmPFN–40 | 2 | 0.046 | −22,66,16 | L frontal pole. |
| dmPFN–41 | 1 | 0.05 | 46,26,48 | R middle frontal gyrus. |
| dmPFN–42 | 1 | 0.05 | 54,18,44 | R middle frontal gyrus. |
| dmPFN–43 | 1 | 0.049 | 62,2,40 | R precentral gyrus. |
| PD‐NC < PD‐MCI | ||||
| INSN‐44 | 5 | 0.034 | −46,−70,48 | L lateral occipital cortex, superior division. |
| CBN2‐45 | 25 | 0.016 | 6,30,−28 | R subcallosal cortex, R frontal pole. |
L/R, right and left hemisphere.