Table 3.
Multiple regression results between significant cluster from the dual‐regression analysis and clinical variables from the MCI diagnostic criteria
| Dual‐regression | TFCE GLM corrected clusters | GLM: Voxel ∼ B1*variable + age + gender + YoE + LEDD | ||||
|---|---|---|---|---|---|---|
|
HC vs. PD‐NC |
Variable | Number of voxels | B1 | Min P‐value | MNI coordinate | Brain region |
| LFPN‐23 | PRM | 6 | 0.23716 | 0.0028 | −6,30,−8 | L subcallosal cortex |
| LFPN‐23 | ToL | 1 | 0.18869 | 0.0074 | −6,26,−4 | L subcallosal cortex |
| MN2‐14 | PoA | 7 | 0.005 | 0.0012 | −30,−94,24 | L occipital pole |
| MN2‐14 | PoA | 3 | 0.0059 | 0.00053 | 34,−86,40 | R cerebral cortex |
| MN2‐14 | PoA | 1 | 0.00591 | 0.00063 | −46,−82,28 | L cerebral cortex |
| FPN‐20 | SRM | 4 | 0.47865 | 9.10E‐005 | 38,18,56 | R middle frontal gyrus |
| FPN‐20 | SRM | 3 | 0.41244 | 0.0011 | 18,−46,76 | R superior parietal lobule |
| FPN‐20 | SRM | 2 | 0.40269 | 0.0029 | 38,−2,68 | R precentral gyrus |
| FPN‐20 | SRM | 1 | 0.36416 | 0.0023 | 22,−26,80 | R postcentral gyrus |
| FPN‐22 | UPDRS | 2 | −0.073 | 0.00046 | 42,−46,68 | R superior parietal lobule |
| FPN‐22 | UPDRS | 2 | −0.08 | 0.00053 | 42,−50,68 | R superior Parietal lobule |
|
HC vs. PD‐MCI |
||||||
| LFPN‐23 | SRM | 1 | −0.2610 | 0.0025 | −30,38,24 | L frontal pole |
| TEMP‐24 | PAL | 1 | −0.7557 | 0.0021 | 62,6,36 | R precentral gyrus |
| VN2‐25 | PAL | 3 | −0.9386 | 0.0088 | −46,−18,52 | L postcentral gyrus |
| PD‐NC vs. PD‐MCI | ||||||
| VAN‐28 | MoCA | 2 | 0.13936 | 0.002277 | 26,−10,40 | R precentral gyrus |
| VAN‐28 | MoCA | 1 | 0.11588 | 0.0042 | 18,−18,40 | R cingulate gyrus, posterior division |
| VAN‐28 | PRM | 10 | 0.16192 | 0.0002 | 18,−14,40 | R cingulate gyrus, anterior division |
| dmPFN‐32 | ToL | 13 | 0.0036 | 0.00064 | −34,−10,76 | L precentral gyrus |
| dmPFN‐32 | ToL | 6 | 0.0037 | 0.0022 | −30,−38,72 | L postcentral gyrus |
Cluster significance was assessed with FSL‐randomise with threshold free cluster enhancement (TFCE) correction for multiple comparisons.
YoE, years of education; LEDD, Levodopa equivalent daily dose; GLM, general linear model; PoA, power of attention; ToL, Tower of London; R/L, right and left hemisphere.